Mouse model for pangolin-origin coronavirus GX/P2V/2017 infection and cross-protection from COVID-19 ZF2001 subunit vaccine  

作　　者：Xiao Qu Yunfei Jia Na Jia Huahao Fan Anqi Zheng Luoyuan Xia Zhenfei Wang Di Tian Sheng Niu Yu Hu Wenxia Tian Zhihai Chen Yigang Tong Yuwei Gao Wuchun Cao Qihui Wang George Fu Gao 

机构地区：[1]CAS Key Laboratory of Pathogen Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,Beijing,China [2]College of Veterinary Medicine,Shanxi Agricultural University,Shanxi,China [3]State Key Laboratory of Pathogen and Biosecurity,Beijing Institute of Microbiology and Epidemiology,Beijing,China [4]Beijing Advanced Innovation Center for Soft Matter Science and Engineering,College of Life Science and Technology,Beijing University of Chemical Technology,Beijing,China [5]Savaid Medical School,University of Chinese Academy of Sciences,Beijing,China [6]Center of Infectious Disease,Beijing Ditan Hospital,Capital Medical University,Beijing,China [7]School of Life Sciences,University of Science and Technology of China,Anhui,China [8]Institute of Military Veterinary Medicine,Academy of Military Medical Sciences,Jilin,China

出　　处：《hLife》2023年第1期35-43,共9页健康科学（英文）

基　　金：supported by the National Key R&D Program of China(2022YFC2303403 and 2021YFC0863400);the National Natural Science Foundation of China(NSFC 82225021 and 32000127);Q.W.is supported by the Youth Innovation Promotion Association CAS(Y2022037);G.F.G.is supported by the Yanqi Lake Meeting organized by the Academic Divisions of CAS.

摘　　要：Many severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)–related coronaviruses have been discovered,constituting potential threats to human health.However,it remains unclear whether the currently available vaccines are effective against these coronaviruses.Here,we constructed a wild-type mouse model to evaluate pathogenicity of the SARS-CoV-2-related pangolin coronavirus GX/P2V/2017 and neutralization efficacy of the approved tandemrepeat SARS-CoV-2 spike receptor-binding domain(RBD)vaccine ZF2001.We found that ZF2001-induced cross-reactive and cross-neutralizing antibodies against GX/P2V/2017,and the vaccination alleviated the pathological lung damage caused by GX/P2V/2017 in mice.These results indicate that RBD may work as a promising candidate for pan-coronavirus vaccine development.

关 键 词：ZF2001 pangolin-origin coronavirus mouse model VACCINE protection 

分 类 号：R37[医药卫生—病原生物学] R186[医药卫生—基础医学]