Anticonvulsant Effect of Xingnaojing Injection on Acute Seizure Models in Mice  

作　　者：Minjuan Sun Xiaoyun Qiu Zhijian Yuan Shuo Zhang Qi Zhang Xiaoli Da Xuming Ji Xuhong Jiang Cenglin Xu Zhong Chen 

机构地区：[1]Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province,School of Pharmaceutical Sciences,Zhejiang Chinese Medical University,Hangzhou 311402,Zhejiang,China [2]Department of Pharmacy,The First Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou 310003,Zhejiang,China [3]School of Basic Medical Sciences,Zhejiang Chinese Medical University,Hangzhou 310053,Zhejiang,China [4]Department of Neurology,The First Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou 310003,Zhejiang,China

出　　处：《Clinical Complementary Medicine and Pharmacology》2023年第3期31-39,共9页临床补充医学和药理学（英文）

基　　金：This work was financially supported by the Natural Science Foun-dation of Zhejiang Province(LD22H310003);the National Natural Science Foundation of China(82173796);the Research Project of Zhe-jiang Chinese Medical University(2022JKJNTZ13).

摘　　要：Background:Epilepsy is characterized by acute recurrent seizures.The control of seizures is largely hampered by the tolerance to current anti-seizure drugs.Complementary anti-convulsant pharmacotherapies are urgently needed.Objective:Here,we aimed to investigate the anti-convulsant effects of Xingnaojing Injection(XNJ)which is an approved Traditional Chinese Medicine injection on different acute seizure models in mice.Methods:The effects of XNJ were tested on the maximal electroshock(MES),pentylenetetrazol(PTZ)and kainic acid(KA)acute seizure models.Also,whether XNJ can directly inhibit hippocampal neuronal firings were exam-ined by in vitro electrophysiology.Results:XNJ could shorten the durations of generalized tonic-clonic seizures in the MES model.It also significantly prolonged the latencies to generalized myo-clonic seizures in the PTZ model.In the KA model,XNJ showed various efficacies including inhibiting the seizure stages,prolonging the latency to the occurrence of the first seizures or generalized seizures,shortening the seizure durations,decreasing the numbers of generalized seizures.In vitro electrophysiological recordings further verified XNJ directly inhibited both the spontaneous and evoked action potentials of hippocampal pyramidal neurons,but did not influence the excitatory or inhibitory synaptic transmissions.Conclusion:These findings proposed XNJ as an alternative anti-convulsant pharmacotherapy for controlling acute epileptic seizures.

关 键 词：Xingnaojing Injection Epileptic seizure Neuronal excitability Traditional Chinese Medicine 

分 类 号：R742.1[医药卫生—神经病学与精神病学]