外泌体非编码RNA在胰腺疾病中的作用  

Role of exosomal non-coding RNA in pancreatic diseases

作　　者：李姗姗 牟作 李满[1] 余佳[1] Li Shanshan;Mou Zuo;Li Man;Yu Jia(Department of Hepatobiliary Surgery,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院肝胆外科,武汉430060

出　　处：《中华肝胆外科杂志》2024年第3期236-240,共5页Chinese Journal of Hepatobiliary Surgery

基　　金：国家自然科学基金(82003063);武汉市中青年医学骨干人才培养项目(武卫生计生(2016)59号)。

摘　　要：外泌体是一种细胞外囊泡,其通过介导蛋白质、核酸、脂质的释放参与调控机体各种信号通路,从而在炎症、肿瘤、免疫、神经系统等病理生理过程中发挥着重要的作用。越来越多的研究表明,外泌体非编码RNA(ncRNA)在胰腺疾病中发挥着重要作用,本文从外泌体ncRNA出发,综述其在急性胰腺炎、胰腺癌等胰腺疾病的发生、诊断与治疗中的作用,以期为临床提供参考。Exosomes are extracellular vesicles that regulate various signaling pathways in the body by mediating the release of proteins,nucleic acids and lipids,thus playing an important role in pathophysiological processes such as inflammation,tumor,immunity and nervous system.More and more studies have shown that exosomal non-coding RNA(ncRNA)plays a crucial role in pancreatic diseases.This article reviews the role of exosome ncRNA in the occurrence,diagnosis and treatment of pancreatic diseases such as acute pancreatitis and pancreatic cancer,in order to provide a reference for clinical practice.

关 键 词：外泌体 非编码RNA 急性胰腺炎 胰腺癌 

分 类 号：R576[医药卫生—消化系统]