口腔黏膜黑色素瘤冷冻消融治疗专家共识  

Expert consensus on cryoablation therapy of oral mucosal melanoma

作　　者：任国欣[1] 孙沫逸 唐瞻贵 李龙江 孟箭[5] 孙志军 刘绍严[7] 何悦[1] 尚伟[8] 李刚[9] 张杰[10] 武和明[11] 李一 黄绍辉[12] 张世周 龚忠诚[14] 王军[15] 王安训[16] 李志勇 黄志权 苏彤 李吉辰 杨凯 李伟忠[22] 谢卫红 席庆[24] 赵科[25] 玄云泽 黄立 孙传政[28] 韩冰[29] 陈彦平 陈文革[31] 吴云腾[1] 魏东亮 郭伟[1] REN Guoxin;SUN Moyi;TANG Zhangui;LI Longjiang;MENG Jian;SUN Zhijun;LIU Shaoyan;HE Yue;SHANG Wei;LI Gang;ZHNAG Jie;WU Heming;LI Yi;HUANG Shaohui;ZHANG Shizhou;GONG Zhongcheng;WANG Jun;WANG Anxun;LI Zhiyong;HUNAG Zhiquan;SU Tong;LI Jichen;YANG Kai;LI Weizhong;XIE Weihong;XI Qing;ZHAO Ke;XUAN Yunze;HUANG Li;SUN Chuanzheng;HAN Bing;CHEN Yanping;CHEN Wenge;WU Yunteng;WEI Dongliang;GUO Wei(Shanghai Ninth People's Hospital,Shanghai Jiaotong University School of Medicine,200011 China;State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration,National Clinical Research Center for Oral Diseases,Shaanxi Key Laboratory of Stomatology,Department of Maxillofacial Oncology,The Third Hospital Affiliated of Air Force Military Medical University,Xi'an;Xiangya Stomatological Hospital Central South University,Changsha;West China Stomatological Hospital,Sichuan University,Chengdu;Xuzhou Central Hospital;Hospital of Stomatology Wuhan University;Cancer Hospital Chinese Academy of Medical Sciences,Beijing;The Affiliated Hospital of Qingdao University;Hospital of Stomatology Xi’an Jiaotong University;Peking University Hospital of Stomatology,Beijing;Affiliated Stomatological Hospital of Nanjing Medical University;China Medical University,Hospital of Stomatology,Shenyang;Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan;The First Affiliated Hospital of Xinjiang Medical University,Urumqi;Gansu Provincial Cancer Hospital,Lanzhou;The First Affiliated Hospital,Sun Yat-sen University,Guangzhou;The Stomatology Hospital,Zhejiang University School of Medicine,Hangzhou;Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou;Xiangya Hospital Central South University,Changsha;The First Affiliated Hospital of Harbin Medical University;The First Affiliated Hospital of Chongqing Medical University;Nanfang Hospital,Southern Medical University,Guangzhou;The First Affiliated Hospital of Zhengzhou University;Chinese PLA General Hospital,Beijing;Guizhou Provincial People’s Hospital,Guiyang;Affiliat

机构地区：[1]上海交通大学医学院附属第九人民医院,200011 [2]口颌系统重建与再生全国重点实验室,国家口腔疾病临床医学研究中心,陕西省口腔疾病临床医学研究中心,空军军医大学第三附属医院口腔颌面头颈肿瘤科 [3]中南大学湘雅口腔医院 [4]四川大学华西口腔医院 [5]徐州市中心医院 [6]武汉大学口腔医院 [7]中国医学科学院肿瘤医院 [8]青岛大学附属医院 [9]西安交通大学口腔医院 [10]北京大学口腔医院 [11]南京医科大学附属口腔医院 [12]中国医科大学附属口腔医院 [13]山东第一医科大学附属省立医院 [14]新疆医科大学第一附属医院 [15]甘肃省肿瘤医院 [16]中山大学附属第一医院 [17]浙江大学医学院附属口腔医院 [18]中山大学孙逸仙纪念医院 [19]中南大学湘雅医院 [20]哈尔滨医科大学附属第一医院 [21]重庆医科大学附属第一医院 [22]南方医科大学南方医院 [23]郑州大学第一附属医院 [24]解放军总医院 [25]贵州省人民医院 [26]延边大学附属医院 [27]福州医科大学附属第一医院 [28]云南省肿瘤医院 [29]吉林大学附属口腔医院 [30]河北医科大学第四医院 [31]山西省人民医院

出　　处：《实用口腔医学杂志》2024年第2期149-155,共7页Journal of Practical Stomatology

基　　金：上海市中央引导地方科技发展资金(编号:YDZX20223100003007);中国抗癌协会CACA指南进临床“蒲公英计划”口腔颌面头颈肿瘤规范诊疗推广专项基金(编号:2023-05-01);2023年上海交通大学医学院附属第九人民医院罕见病注册登记项目(编号:JYHJB202307)。

摘　　要：冷冻消融治疗有着悠久的历史,其抗肿瘤机制、组织病理变化已较明确,且大量临床实践表明冷冻消融治疗安全有效,理论上是一种理想的肿瘤治疗手段。以往一直受冷媒和冷冻设备的限制,制约了其疗效和临床应用。随着以氩氦刀为代表的新一代冷冻消融设备的出现,在制冷效率、消融范围、精准测温等方面取得了长足的进步,极大地推动了肿瘤冷冻消融技术的推广。该共识系统性地总结了冷冻消融技术的机制、口腔黏膜黑色素瘤冷冻治疗的适应证、临床治疗流程、不良反应及处理、冷冻联合治疗等,旨在为口腔黏膜黑色素瘤冷冻消融治疗的规范化开展提供参考。Cryoablation therapy with explicit anti-tumor mechanisms and histopathological manifestations has a long history.A large number of clinical practice has shown that cryoablation therapy is safe and effective,making it an ideal tumor treatment method in theory.Previously,its efficacy and clinical application were constrained by the limitations of refrigerants and refrigeration equipment.With the development of the new generation of cryoablation equipment represented by argon helium knives,significant progress has been made in refrigeration efficiency,ablation range,and precise temperature measurement,greatly promoting the progression of tumor cryoablation technology.This consensus systematically summarizes the mechanism of cryoablation technology,indications for oral mucosal melanoma(OMM)cryotherapy,clinical treatment process,adverse reactions and management,cryotherapy combination therapy,etc.,aiming to provide reference for carrying out the standardized cryoablation therapy of OMM.

关 键 词：口腔黏膜 黑色素瘤 冷冻消融治疗 专家共识 

分 类 号：R739.8[医药卫生—肿瘤]