5-氮杂胞苷对肿瘤抑制作用研究  

Study on the inhibitory effect of 5-azacytidine on tumor

作　　者：高冰 邵国 GAO Bing;SHAO Guo(Department of Public Health,International College,Krirk University,Bangkok 10220,Thailand)

机构地区：[1]泰国格乐大学国际学院公共卫生学系,泰国曼谷10220

出　　处：《包头医学院学报》2024年第4期87-90,96,共5页Journal of Baotou Medical College

基　　金：国家自然科学基金(82060337,82071479,31860307);内蒙古自然科学基金(2020MS0807,02020MS08171);深圳市龙岗区医疗卫生科技计划项目(LGKCYLWS2021000033,LGKCYLWS2023025);深圳市科技计划计划项目基础研究面上项目(JCYJ20220531092412028,JCYJ20230807121306012)。

摘　　要：DNA甲基化异常是肿瘤发生发展的重要机制之一。DNA甲基化是建立和维持组织特异性基因表达的核心,也是调控基因表达的机制,对肿瘤的发生起着重要作用,尤其是抑癌基因高甲基化的异常状态,在肿瘤的发生、诊断、鉴别、预后、治疗等方面具有重要意义。此外,DNA甲基化与去甲基化是可逆的过程。5-氮杂胞苷(5-Azacytidine)通过抑制DNA甲基转移酶,降低高甲基化抑癌基因的甲基化水平,从而达到肿瘤治疗的目标。5-氮杂胞苷在白血病、骨髓增生异常综合征、前驱性骨髓细胞肿瘤和实体肿瘤中,通过DNA去甲基化作用抑制细胞增殖,促使细胞分化,具有治疗潜力,但其生物利用度低且长期使用可能引起DNA损伤和细胞毒性,因此需要寻找更好的给药方法和剂量调控策略,以验证和优化其抗肿瘤疗效并推动临床应用。Abnormal DNA methylation is one of the important mechanisms of tumorigenesis and development.It is the core of establishing and maintaining tissue-specific gene expression,and also the mechanism of regulating gene expression,which plays an important role in tumorigenesis.In particular,the abnormal state of hypermethylation of tumor suppressor genes is of great significance in the occurrence,diagnosis,identification,prognosis and treatment of tumors.In addition,DNA methylation and demethylation are reversible processes.5-Azacytidine can reduce the methylation level of hypermethylated tumor suppressor genes by inhibiting DNA methyltransferase,so as to achieve the goal of tumor treatment.In leukemia,myelodysplastic syndrome,precursor bone marrow cell tumors and solid tumors,5-azacytidine inhibits cell proliferation and promotes cell differentiation through DNA demethylation,which has therapeutic potential.However,its low bioavailability and long-term use may cause DNA damage and cytotoxicity.Therefore,it is necessary to find better administration methods and dose regulation strategies to verify and optimize its anti-tumor efficacy and promote clinical application.

关 键 词：5-氮杂胞苷 抗肿瘤 DNA甲基化 

分 类 号：R730.5[医药卫生—肿瘤]