黄芪桂枝五物加味汤联合甲钴胺治疗紫杉醇化疗后周围神经病变疗效观察  

Efficacy of modified Decoction of Five Drugs Including Astragalus Root and Cinnamon Twig combined with methylcobalamin on peripheral neuropathy after paclitaxel chemotherapy

作　　者：李尚朋 齐婧[2] 高杰红 王奇[2] 王茂[2] 吴少锋[2] 代引海[2] LI Shangpeng;QI Jing;GAO Jiehong;WANG Qi;WANG Mao;WU Shaofeng;DAI Yinhai(The Second Clinical Medical College of Shaanxi University of Chinese Medicine,Xianyang 712000,Shaanxi,China;The Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000,Shaanxi,China)

机构地区：[1]陕西中医药大学第二临床医学院,陕西咸阳712000 [2]陕西中医药大学第二附属医院,陕西咸阳712000

出　　处：《现代中西医结合杂志》2024年第4期480-484,共5页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：陕西省中医药管理局科研项目(2021-GJ-LC012)。

摘　　要：目的观察黄芪桂枝五物加味汤联合甲钴胺治疗紫杉醇化疗后周围神经病变的临床疗效。方法选取2021年9月—2022年9月于陕西中医药大学第二附属医院肿瘤乳腺外科住院治疗的恶性肿瘤患者96例,根据随机数字表法将患者分为3组,加味汤组35例给予黄芪桂枝五物加味汤联合甲钴胺治疗,原汤组32例给予黄芪桂枝五物汤联合甲钴胺治疗,对照组29例给予甲钴胺治疗,3组均连续治疗14 d。观察3组治疗前后周围神经病变分级、体力状况(ECOG)评分、卡氏功能状态(KPS)评分及治疗14 d后的临床疗效和治疗安全性。结果与治疗前比较,3组治疗后周围神经病变分级、ECOG评分、KPS评分均明显改善(P均<0.05);治疗后组间比较,加味汤组、原汤组周围神经病变分级、ECOG评分与对照组比较差异均无统计学意义(P均>0.05),KPS评分均明显高于对照组(P均<0.05),加味汤组和原汤组周围神经病变分级、ECOG评分、KPS评分比较差异均无统计学意义(P均>0.05)。3组治疗总有效率比较差异无统计学意义(P均>0.05),且均未出现不良反应。结论黄芪桂枝五物加味汤联合甲钴胺可减轻紫杉醇化疗后周围神经病变,改善患者体力状况和身体功能状态。Objective It is to observe the clinical efficacy of modified Decoction of Five Drugs Including Astragalus Root and Cinnamon Twig combined with methylcobalamin in the treatment of peripheral neuropathy after paclitaxel chemotherapy.Methods Ninety-six patients with malignant tumors who were hospitalized in the Department of Oncology and Breast Surgery of the Second Affiliated Hospital of Shaanxi University of Chinese Medicine from September 2021 to September 2022 were selected and divided into 3 groups according to the method of randomized numerical table,35 cases in the modified decoction group were treated with modified Decoction of Five Drugs Including Astragalus Root and Cinnamon Twig combined with methylcobalamin,32 cases in the basic decoction group were treated with Decoction of Five Drugs Including Astragalus Root and Cinnamon Twig combined with methylcobalamin,29 cases in the control group were treated with methylcobalamin,all the three groups were treated continuously for 14 days.The peripheral neuropathy classification,the ECOG scores and KPS scores before and after treatment,as well as the clinical efficacy and treatment safety of after 14 days of treatment were observed in the three groups.Results Compared with before treatment,the peripheral neuropathy classification,ECOG scores and the KPS scores of the three groups and basic decoction group were significantly improved after treatment(all P<0.05);the differences in the peripheral neuropathy classification,ECOG scores of the modified decoction group and basic decoction group were not statistical significant compared with the control group,but the KPS score were significantly higher than that of the control group(both P>0.05),there were no significant differences in peripheral neuropathy classification,ECOG scores and KPS scores between the modified decoction group and basic decoction group(all P>0.05).The differences in the total effective rate of treatment among the three groups were not statistically significant(all P>0.05),and no adverse reactions

关 键 词：周围神经病变 紫杉醇 黄芪桂枝五物加味汤 甲钴胺 

分 类 号：R745[医药卫生—神经病学与精神病学]