金蓉颗粒联合新辅助化疗治疗三阴性乳腺癌患者的临床疗效及对其血管生成相关因子、氧化应激、肿瘤标志物水平的影响  

Jinrong Granules Combined with Neoadjuvant Chemotherapy for Triple-Negative Breast Cancer:Clinical Efficacy and Effects on Levels of Angiogenesis-Related Factors,Oxidative Stress,and Tumor Markers

作　　者：张霞 黄关旋 莫国臻 陈暖 罗健麟 石宇昕 ZHANG Xia;HUANG Guan-xuan;MO Guo-zhen;CHEN Nuan;LUO Jian-in;SHI Yu-xin(Zhujiang Hospital of Southern Medical University,Guangzhou Guangdong 510220)

机构地区：[1]南方医科大学珠江医院,广东广州510220

出　　处：《世界中西医结合杂志》2024年第3期556-560,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：广东省医院药学研究基金(2023A15)。

摘　　要：目的探讨金蓉颗粒联合新辅助化疗治疗三阴性乳腺癌(Triple negative breast cancer,TNBC)患者的临床疗效及对其血管生成相关因子、氧化应激、肿瘤标志物水平的影响。方法选取2020年4月—2022年4月期间南方医科大学珠江医院收治的94例TNBC患者作为研究对象,按随机数字表法分为对照组和观察组,每组各47例。对照组采用TAC化疗方案治疗,观察组在对照组基础上加用金蓉颗粒治疗。21 d为1个治疗周期,连续治疗4个周期。观察比较两组患者临床疗效、生活质量精简量表(QOL-BREF)、血管生成相关因子[血管内皮生长因子(Vascular endothelial growth factor,VEGF)及血管内皮生长因子受体2(Vascular endothelial growth factor receptor 2,VEGFR2)],氧化应激指标[血清丙二醛(Malondialdehyde,MDA)、超氧化物歧化酶(Superoxide dismutase,SOD)、一氧化氮(Nitric oxide,NO)、谷胱甘肽过氧化物酶活性(Glutathione peroxidase activity,GSH-PX)],肿瘤标志物[癌胚抗原(Carcinoembryonic antigen,CEA)、糖类抗原125(Carbohydrate antigen125,CA125)、糖类抗原153(Carbohydrate antigen153,CA153)]、T淋巴细胞亚群(CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))水平。结果治疗后观察组临床总有效率91.49%(43/47)高于对照组76.60%(36/47),差异有统计学意义(P<0.05)。治疗后两组患者生活质量量表各维度评分均较治疗前升高,差异有统计学意义(P<0.05);且观察组患者生活质量量表各维度评分均明显高于对照组,差异有统计学意义(P<0.05)。治疗后两组患者肿瘤标志物CA125、CA153、CEA水平均较治疗前降低,差异有统计学意义(P<0.05);且观察组患者肿瘤标志物CA125、CA153、CEA水平均明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者氧化应激MDA水平均升高,SOD、NO、GSH-PX水平均降低,差异有统计学意义(P<0.05);且观察组患者氧化应激MDA水平明显高于对照组,SOD、NO、GSH-PX水平均明显低于对照组,差异有统计�Objective To investigate the clinical efficacy of Jinrong Granules combined with neoadjuvant chemotherapy in the patients with triple-negative breast cancer(TNBC)and the effects of this treatment regimen on the levels of angiogenesis-related factors,oxidative stress,and tumor markers.Methods A total of 94 TNBC patients treated in the Zhujiang Hospital of Southern Medical University from April 2020 to April 2022 were selected and assigned into a control group and an observation group by the random number table method,with 47 patients in each group.The control group was treated with TAC(taxotere,adriamycin,and cyclophosphamide)chemotherapy,and the observation group with Jinrong Granules on the basis of the therapy in the control group.Each treatment course lasted for 21 days,and both groups were treated for 4 consecutive courses.The two groups were compared in terms of clinical efficacy,World Health Organization quality of life-brief(WHOQOL-BREF)score,angiogenesis-related factors[vascular endothelial growth factor(VEGF)and vascular endothelial growth factor receptor 2(VEGFR2)],oxidative stress indicators[malondialdehyde(MDA),superoxide dismutase(SOD),nitric oxide(NO),and glutathione peroxidase(GSH-PX)],tumor markers[carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125),and carbohydrate antigen 153(CA153)],and T lymphocyte subsets(CD4^(+),CD8^(+),and CD4^(+)/CD8^(+)).Results After treatment,the total response rate in the observation group was 91.49%(43/47),which was higher than that(76.60%,36/47)in the control group(P<0.05).After treatment,the scores of all dimensions in the WHOQOL-BREF rose compared with those before treatment(P<0.05),and the observation group had higher scores than the control group(P<0.05).The treatment in both groups lowered the levels of CA125,CA153,and CEA(P<0.05),and the observation group had lower levels than the control group after treatment(P<0.05).The treatment in both groups elevated the MDA level and lowered the SOD,NO,and GSH-PX levels(P<0.05),and the observation group had high

关 键 词：金蓉颗粒 三阴性乳腺癌 新辅助化疗 

分 类 号：R737.9[医药卫生—肿瘤]