安肠消溃穴位埋线法联合美沙拉嗪治疗肾脾阳虚型溃疡性结肠炎患者的疗效及对其血清炎症因子、免疫功能的影响  

Effect of Anchang Xiaokui Acupoint Catgut Embedding Combined with Mesalazine on Ulcerative Colitis of Kidney and Spleen Yang Deficiency Type and Its Influence on Serum Inflammatory Factors and Immune Function

作　　者：程怡佳 黄玲 CHENG Yi-jia;HUANG Ling(Department of Proctology,Zhangjiagang Hospital of Traditional Chinese Medicine,Zhangjiagang Jiangsu 215600)

机构地区：[1]张家港市中医医院肛肠科,江苏张家港215600

出　　处：《世界中西医结合杂志》2024年第3期586-590,595,共6页World Journal of Integrated Traditional and Western Medicine

基　　金：张家港市卫生青年科技计划项目(ZJGQNKJ202131)。

摘　　要：目的探讨安肠消溃穴位埋线法联合美沙拉嗪治疗肾脾阳虚型溃疡性结肠炎(Ulcerative colitis,UC)的效果及对血清炎症因子、免疫功能的影响。方法选取2020年10月—2022年9月期间张家港市中医医院门诊收治的UC患者90例作为研究对象,依据简单随机数字表法分为对照组和研究组,每组各45例。对照组采取美沙拉嗪肠溶片治疗,研究组在对照组基础上采取安肠消溃穴位埋线法。治疗4周后,观察比较两组患者治疗效果、治疗安全性及治疗前后中医证候积分、内镜评分、炎症因子[肿瘤坏死因子-α(Tumor necrosis factor-alpha,TNF-α)、白细胞介素-6(Interleukin-6,IL-6)、干扰素-γ(Interferon-gamma,IFN-γ)]、免疫功能(CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+))水平。结果(1)中医证候积分:治疗后两组患者主症与次症分值均较治疗前降低,差异有统计学意义(P<0.05);且研究组主症与次症分值均较对照组明显降低,差异有统计学意义(P<0.05)。(2)内镜评分:治疗后两组患者内镜评分较治疗前下降,且研究组内镜评分较对照组明显降低,差异有统计学意义(P<0.05)。(3)治疗效果:治疗后研究组临床总有效率95.56%(43/45)明显高于对照组82.22%(37/45),差异有统计学意义(P<0.05)。(4)炎症因子:治疗后两组患者血清TNF-α、IL-6、IFN-γ水平均较治疗前降低,差异有统计学意义(P<0.05);且研究组血清TNF-α、IL-6、IFN-γ水平均较对照组明显降低,差异有统计学意义(P<0.05)。(5)免疫功能:治疗后两组患者CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均较治疗前升高,差异有统计学意义(P<0.05);且研究组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均较对照组明显升高,差异有统计学意义(P<0.05)。(6)安全性:治疗期间,两组患者均未发生不良反应,且治疗后血脂、肝功能、血常规等检查未见异常。结论安肠消溃穴位埋线法联合美沙拉嗪治疗肾脾阳虚型UC可缓解患者临床症状,下调炎症因�Objective To explore the effect of Anchang Xiaokui acupoint catgut embedding combined with mesalazine in the treatment of ulcerative colitis(UC)of kidney and spleen yang deficiency type and its influence on serum inflammatory factors and immune function.Methods A total of 90 patients with UC admitted in our hospital from October 2020 to September 2022 were selected as the study subjects and divided into a study group and a control group according to simple random number table method,with 45 patients in each group.The control group was treated with mesalazine enteric-coated tablets,and the study group was treated with the method of embedding thread at the acupoint of Anchang Xiaokui in addition to the treatment received by the control group.After 4 weeks of treatment,the therapeutic effect,treatment safety,traditional Chinese medicine(TCM)syndrome scores,endoscopic scores,inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interferon-γ(IFN-γ)]and immune function(CD3^(+),CD4^(+),CD4^(+)/CD8^(+))levels were compared between the two groups.Results(1)TCM syndrome score:After treatment,the scores of main and secondary symptoms in the two groups decreased compared with those before treatment(P<0.05).Additionally,thescores of main and secondary symptoms in the study group were significantly lower than those in the control group(P<0.05).(2)Endoscopic score:After treatment,the endoscopic scores of the two groups were lower than those before treatment,and the score of the study group was lower than that of the control group(P<0.05).(3)Treatment effect:The total effective rate of treatment in the study group(95.56%)was higher than that in the control group(82.22%)(P<0.05).(4)Inflammatory factors:After treatment,the serum levels of TNF-α,IL-6,and IFN-γin both groups decreased compared to before treatment,with statistical significance(P<0.05).Moreover,the levels of these inflammatory factors in the study group were significantly lower than those in the control group(P<0.05).(5)Immune function:After tr

关 键 词：安肠消溃穴位埋线法 美沙拉嗪 肾脾阳虚 溃疡性结肠炎 炎症因子 免疫功能 

分 类 号：R574.62[医药卫生—消化系统]