阿尔茨海默病患者血清CXCL16、Trx80水平与认知功能和预后的关系  

The relationship between serum CXCL16,Trx80,and cognitive function/prognosis in Alzheimer′s disease patients

作　　者：刘龙芳 岳丽 孙佳瑶 Liu Longfang;Yue Li;Sun Jiayao(The Second Department of Neurology,Zhangjiakou First Hospital,Zhangjiakou 075000,China)

机构地区：[1]张家口市第一医院神经内二科,张家口075000

出　　处：《中国医师杂志》2024年第3期387-391,396,共6页Journal of Chinese Physician

基　　金：河北省医学科学研究课题计划(20201601);张家口市重点研发计划项目(2121112D)。

摘　　要：目的探讨阿尔茨海默病(AD)患者血清C-X-C基序趋化因子配体16(CXCL16)、硫氧还蛋白80(Trx80)与认知功能和预后的关系。方法选取2020年1月至2021年8月张家口市第一医院收治的189例AD患者为AD组,另选取同期110例于本院体检的健康志愿者为对照组。采用酶联免疫吸附法检测血清CXCL16、Trx80水平,通过简易精神状态检查量表(MMSE)评分评估认知功能。采用Spearman相关性方法分析AD患者血清CXCL16、Trx80水平与MMSE评分的相关性。189例AD患者根据预后情况分为预后不良组和预后良好组,采用单因素及多因素logistic回归方法分析AD患者预后不良的影响因素,受试者工作特征(ROC)曲线分析血清CXCL16、Trx80水平对AD患者预后不良的预测价值。结果与对照组比较,AD组血清CXCL16、Trx80水平更高,MMSE评分更低(均P<0.05)。Spearman相关性分析显示,AD患者血清CXCL16、Trx80水平与MMSE评分呈负相关(均P<0.05)。随访1年,189例AD患者预后不良率为32.80%(62/189)。单因素分析显示,年龄、病程、β-淀粉样蛋白(Aβ)1-40、Aβ1-42、MMSE评分、CXCL16和Trx80与AD患者预后不良有关(均P<0.05)。多因素logistic回归分析显示,年龄增加、病程延长和CXCL16、Trx80水平升高为AD患者预后不良的危险因素(P<0.05),MMSE评分增加为其保护因素(均P<0.05)。ROC曲线分析显示,MMSE评分、CXCL16、Trx80、CXCL16+Trx80两项联合、MMSE评分+CXCL16+Trx80三项联合预测AD患者预后不良的曲线下面积(AUC)分别为0.750、0.763、0.771、0.851、0.896,三项联合预测AD患者预后不良的AUC最大。结论 AD患者血清CXCL16、Trx80水平升高,与认知功能降低、预后不良有关,可能成为AD患者预后不良的辅助预测指标。Objective To explore the relationship between serum C-X-C motif chemokine ligand 16(CXCL16)and thioredoxin 80(Trx80)in patients with Alzheimer′s disease(AD)and cognitive function and prognosis.Methods A total of 189 AD patients admitted to the Zhangjiakou First Hospital from January 2020 to August 2021 were selected as the AD group,and 110 healthy volunteers who underwent physical examinations in our hospital during the same period were selected as the control group.The serum levels of CXCL16 and Trx80 were detected using enzyme-linked immunosorbent assay(ELISA),and cognitive function was evaluated using the Mini Mental State Examination(MMSE)score.The Spearman correlation method was used to analyze the correlation between serum CXCL16,Trx80 levels and MMSE scores in AD patients.189 AD patients were divided into poor prognosis group and good prognosis group based on their prognosis.Univariate and multivariate logistic regression methods were used to analyze the influencing factors of poor prognosis in AD patients.Receiver operating characteristic(ROC)curves were used to analyze the predictive value of serum CXCL16 and Trx80 levels for poor prognosis in AD patients.Results Compared with the control group,the AD group had higher serum levels of CXCL16 and Trx80,and lower MMSE scores(all P<0.05).Spearman correlation analysis showed that the serum levels of CXCL16 and Trx80 in AD patients were negatively correlated with MMSE scores(all P<0.05).After a one-year follow-up,the poor prognosis rate of 189 AD patients was 32.80%(62/189).Univariate analysis showed that age,disease duration,β-amyloid protein(Aβ)1-40,Aβ1-42,MMSE score,CXCL16,and Trx80 are associated with poor prognosis in AD patients(all P<0.05).Multivariate logistic regression analysis showed that age,prolonged disease course,and elevated levels of CXCL16 and Trx80 were risk factors for poor prognosis in AD patients(all P<0.05),while an increase in MMSE score was a protective factor(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of

关 键 词：阿尔茨海默病 趋化因子CXCL16 硫氧还蛋白80 认知 

分 类 号：R749.16[医药卫生—神经病学与精神病学]