TMEM家族成员与非肿瘤疾病的研究进展  

Research progress on TMEM family members and non tumor diseases

作　　者：杨柳 田慧 冀媛媛 韩晓芳[1] Yang Liu;Tian Hui;Ji Yuanyuan;Han Xiaofang(Department of Central Laboratory,Shanxi Provincial People′s Hospital,Taiyuan 030012,China)

机构地区：[1]山西省人民医院中心实验室,太原030012

出　　处：《中国医师杂志》2024年第3期470-473,共4页Journal of Chinese Physician

基　　金：国家自然科学基金(82101689);山西省自然科学基金(201901D111443)。

摘　　要：TMEM家族广泛分布于质膜和细胞器膜,具有多种生物学功能。TMEM家族在不同疾病中有不同的功能和作用机制。最近研究显示,TMEM家族成员在非肿瘤疾病的发病过程中扮演着重要角色,尤其在心血管、呼吸系统和神经系统疾病中表现突出,如动脉粥样硬化、帕金森病、抑郁症等。综述TMEM家族在非肿瘤疾病中的作用机制,对进一步揭示疾病机制及阐明TMEM家族成员的生物学功能具有重要意义,为疾病的治疗策略提供新的角度。The TMEM family is widely distributed in the plasma membrane and organelle membrane,and has multiple biological functions.The TMEM family has different functions and mechanisms of action in different diseases.Recent research shows that TMEM family members play an important role in the pathogenesis of non tumor diseases,especially in cardiovascular,respiratory and nervous system diseases,such as atherosclerosis,Parkinson′s disease,depression,etc.This article reviews the mechanism of action of the TMEM family in non tumor diseases,which is of great significance for further revealing the disease mechanism and elucidating the biological functions of TMEM family members,and provides a new perspective for disease treatment strategies.

关 键 词：跨膜蛋白 非肿瘤疾病 

分 类 号：R363[医药卫生—病理学]