Uncovering the IL-1β-PCAF-NNT axis:A new player in ferroptosis and tumor immune evasion  

作　　者：Qidong Li Boyi Gan 

机构地区：[1]Department of Experimental Radiation Oncology,The University of Texas MD Anderson Cancer Center,Houston,TX,USA [2]The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences,Houston,TX,USA

出　　处：《Cancer Communications》2023年第9期1048-1050,共3页癌症通讯（英文）

基　　金：University of Texas MD Anderson Cancer Center,National Institutes of Health,Grant/Award Numbers:R01CA181196,R01CA244144,R01CA247992,R01CA269646,U54CA274220;Cancer Prevention&Research Institute of Texas,Grant/Award Numbers:RP220258,RP230072;Cancer Center Support,Grant/Award Number:P30 CA016672;National Cancer Institute。

摘　　要：Chronic inflammation is recognized as a crucial hallmark of cancer.Interleukin-1β(IL-1β),one of the proinflammatory cytokines,plays an ambiguous or even contradictory role in cancer development[1].While increased expression of IL-1βin the tumor microenvironment is associated with tumor development,and invasiveness[1],it has also shown anti-tumorigenic effects in other contexts[2].Therefore,it is difficult to define IL-1β’s role as either tumor-promoting or anti-tumorigenic in cancers.Further investigation of IL-1βin specific contexts is essential to comprehensively understand its role in cancers.

关 键 词：tumor inflammation INTERLEUKIN 

分 类 号：R73[医药卫生—肿瘤]