黄连上清胶囊联合替硝唑对慢性牙周炎患者牙周症状及龈沟液炎症因子水平的影响  

Effect of Huanglian Shangqing Capsule combined with Tinidazole on periodontal symptoms and gingival crevicular fluid inflammatory factors in patients with chronic periodontitis

作　　者：潘晓勤 刘超[2] PAN Xiaoqin;LIU Chao(Department of Stomatology,Nanjing Lishui District Stomatological Disease Prevention and Control Hospital,Jiangsu Province,Nanjing 211200,China;Department of Orthodontics,Nanjing Stomatological Hospital,Jiangsu Province,Nanjing 210018,China)

机构地区：[1]南京市溧水区口腔病防治院口腔科,江苏南京211200 [2]南京市口腔医院正畸科,江苏南京210018

出　　处：《中国当代医药》2024年第9期100-103,107,共5页China Modern Medicine

基　　金：江苏省南京市卫生科技发展专项资金项目计划(ZKX22055)。

摘　　要：目的探讨黄连上清胶囊联合替硝唑对慢性牙周炎患者牙周症状及龈沟液炎症因子水平的影响。方法选取南京市溧水区口腔病防治院2021年6月至2023年6月收治的80例慢性牙周炎患者作为研究对象。按照随机数字表法将其分为对照组(n=40)与观察组(n=40)。对照组采用替硝唑片治疗,观察组采用黄连上清胶囊联合替硝唑治疗。比较两组治疗效果、牙周指标、龈沟液炎症因子水平[乳铁蛋白(LF)、可溶性细胞间黏附分子-1(sICAM-1)、白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)]以及药物不良反应。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。两组治疗前牙周指标和炎症因子水平比较,差异无统计学意义(P>0.05);两组治疗后牙周指标、炎症因子水平均低于本组治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。两组均未发生明显不良反应。结论黄连上清胶囊联合替硝唑治疗慢性牙周炎患者利于改善牙周症状,减轻炎症反应,且不会引起明显不良反应,临床应用安全可靠。Objective To explore the effects of Huanglian Shangqing Capsule combined with Tinidazole on periodontal symptoms and gingival crevicular fluid inflammatory factors in patients with chronic periodontitis.Methods A total of 80 pa-tients with chronic periodontitis admitted to Nanjing Lishui District Stomatological Disease Prevention and Control Hospital from June 2021 to June 2023 were selected as the research objects.They were divided into control group(40 cases)and ob-servation group(40 cases)according to random number table method.The control group was treated with Tinidazole,and the observation group was treated with Huanglian Shangqing Capsule combined with Tinidazole.The therapeutic effect,peri-odontal indexes,gingival crevicular fluid inflammatory factor levels(lactoferrin[LF],soluble intercellular adhesion molecule-1[sICAM-1],interleukin-8[IL-8],tumor necrosis factor-α[TNF-α])and adverse drug reaction were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,and the differ-ence was statistically significant(P<0.05).The levels of periodontal indexes and inflammatory factors were no significant differences between the two groups before treatment(P>0.05).The levels of periodontal indexes and inflammatory factors in two groups after treatment were lower than those before treatment,and the observation group was lower than the control group,with statistically significant(P<0.05).There were no obvious adverse reactions occurring in both groups.Conclusion Huanglian Shangqing Capsule combined with Tinidazole in the treatment of chronic periodontitis patients can improve peri-odontal symptoms,reduce inflammation,and do not cause obvious adverse reactions,clinical application is safe and reliable.

关 键 词：慢性牙周炎 黄连上清胶囊 替硝唑 牙周症状 龈沟液炎症因子 

分 类 号：R781.4[医药卫生—口腔医学]