1914例女性体检者HPV基因型及高危因素分析  

Analysis of HPV genotypes and risk factors in 1914 female physical examinations

作　　者：赵倩 Zhao Qian(Department of Gynecology,Jiangsu Haibin Rehabilitation Hospital,Lianyungang 222000,China)

机构地区：[1]江苏省海滨康复医院妇科,江苏连云港222000

出　　处：《实用妇科内分泌电子杂志》2024年第2期31-33,67,共4页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的探讨女性体检者宫颈人乳头瘤病毒(HPV)感染情况、基因型分布及高危因素。方法选取1914例行宫颈脱落细胞HPV23分型检测的体检者为研究对象,采用巢式PCR和焦磷酸测序技术检测宫颈脱落细胞中HPV分型,收集整理所有受试者一般资料、月经情况、婚育史及生殖道疾病史等,通过对调查结果进行统计分析,分析HPV感染的高危因素。结果1914例受试者中,HPV阳性受试者占比9.82%(188/1914)。检测HR-HPV型别为16类。其中,检出率最高的是HPV53型,占15.96%(30/188),其次是HPV52型,占15.43%(29/188)。单因素分析显示:饮酒、性伴侣>1个、性生活频率>4次/月、伴有宫颈糜烂是HPV感染的因素(P<0.05)。Logistic回归分析显示:饮酒、性伴侣>1个、性生活频率>4次/月、伴有宫颈糜烂是HPV感染的独立因素(P<0.05)。结论HPVDNA基因型检测能为HPV疫苗的研制及宫颈癌早期筛查提供依据,帮助高危人群早预防、早诊断、早治疗。Objective To investigate the infection status,genotype distribution and risk factors of cervical human papillomavirus(HPV)in female physical examiners.Methods In 1914,physical examiners who underwent HPV 23 typing test for cervical exfoliated cells were selected as the research objects,and the HPV typing in cervical exfoliated cells was detected by nid-based PCR and pyrosequencing technology.General information,menstrual status,marital and reproductive history and reproductive tract disease history of all subjects were collected and analyzed statistically.The risk factors of HPV infection were analyzed.Results Among the 1914 subjects,HPV positive subjects accounted for 9.82%(188/1914).The HR-HPV types were 16.The highest detection rate was HPV53,accounting for 15.96%(30/188),followed by HPV52,accounting for 15.43%(29/188).Univariate analysis showed that drinking alcohol,sexual partner>1,sexual frequency>4 times/month,accompanied by cervical erosion were the factors of HPV infection(P<0.05).Logistic regression analysis showed that drinking alcohol,sexual partner>1,sexual frequency>4 times/month,accompanied by cervical erosion were independent factors of HPV infection(P<0.05).Conclusion HPV DNA genotype detection can provide the basis for the development of HPV vaccine and the early screening of cervical cancer,and help high-risk groups to prevent,diagnose and treat early.

关 键 词：宫颈人乳头瘤病毒 宫颈肿瘤 基因型 危险因素 

分 类 号：R737.33[医药卫生—肿瘤]