SPC24和CALR在子宫内膜癌组织中的表达及其临床病理意义  

Expression of SPC24 and CALR in Endometrial Carcinoma and Their Clinicopathological Significance

作　　者：杨文青 李文思 马廷江 YANG Wenqing;LI Wensi;MA Tingjiang(Department of Pathology,Ningyang County First People's Hospital,Tai'an,Shandong Province,271400 China)

机构地区：[1]山东省宁阳县第一人民医院病理科,山东泰安271400

出　　处：《系统医学》2024年第3期164-167,共4页Systems Medicine

摘　　要：目的研究子宫内膜癌组织中SPC24与钙网蛋白(Calreticulin,CALR)表达情况及其临床意义。方法选取2019年9月—2023年9月山东省宁阳县第一人民医院收治的80例子宫内膜癌患者为研究组,另以同期在本院进行检查的80例子宫内膜组织正常的女性为对照组,两组术中采集到的组织标本均采用免疫组化染色法对SPC24、CALR表达情况进行检测。结果研究组SPC24、CALR阳性率分别为75.00%、68.75%,高于对照组的23.75%、18.75%,差异有统计学意义(P均<0.05)。SPC24、CALR表达情况会受到FIGO分期、淋巴结转移、分化程度、子宫肌层浸润深度的影响。结论子宫内膜癌组织中SPC24、CALR阳性率较高,且其表达情况会直接受到患者临床病理表现的影响。Objective To study the expression of SPC24 and calreticulin(CALR)in endometrial cancer tissues and its clinical significance.Methods A total of 80 cases of endometrial cancer patients admitted to Ningyang County First People's Hospital from September 2019 to September 2023 were selected as the study group,and 80 cases of women with normal endometrial tissue examined in the hospital during the same period were used as the control group.The expressions of SPC24 and CALR were detected by immunohistochemical staining in the tissue samples collected in both groups.Results The positive rates of SPC24 and CALR in the study group were 75.00%and 68.75%,respec⁃tively,higher than those in the control group(23.75%and 18.75%),and the differences were statistically significant(both P<0.05).The expressions of SPC24 and CALR is influenced by FIGO staging,lymph node metastasis,degree of differentiation and depth of uterine myometria infiltration.Conclusion The positive rates of SPC24 and CALR were higher in endometrial carcinoma tissues,and their expressions were directly influenced by the clinical and pathologi⁃cal manifestations of patients.

关 键 词：子宫内膜癌 SPC24 钙网蛋白 临床病理表现 

分 类 号：R737.3[医药卫生—肿瘤]