多奈哌齐联合丁苯酞治疗阿尔茨海默病作用机制的meta分析  

Meta-analysis on the mechanism of Butylphthalide combined with Donepezil in the treatment of Alzheimer′s disease

作　　者：王慧娟 叶端玲 许文勇[2] WANG Huijuan;YE Duanling;XU Wenyong(College of Integrated Traditional Chinese and Western Medicine,Fujian Traditional Chinese Medicine University,Fujian Province,Fuzhou350122,China;Department of Neurology,Xiamen Third Hospital Affiliated to Fujian Traditional Chinese Medicine University,Fujian Province,Xiamen361100,China)

机构地区：[1]福建中医药大学中西医结合学院,福建福州350122 [2]福建中医药大学附属第三医院神经内科,福建厦门361100

出　　处：《中国当代医药》2024年第10期22-26,共5页China Modern Medicine

摘　　要：目的通过meta分析评价多奈哌齐联合丁苯酞治疗阿尔茨海默病(AD)的疗效,并初步探讨其潜在作用机制。方法计算机检索从建库以来至2023年3月知网、万方、PubMed、国际临床试验注册平台(ICTRP)和循证医学图书馆(The Cochrane Library)数据库中与多奈哌齐联合丁苯酞(以下称联合治疗组)治疗AD相关的文献资料,采用Revman 5.4软件进行meta分析。结果在本研究中,共纳入14项随机对照试验,联合治疗组包括630例患者,对照组(单用多奈哌齐)638例患者。meta分析结果表明,与对照组相比,联合治疗组在治疗总有效率、简易智力状态检查量表(MMSE)评分、阿尔茨海默病评估量表-认知量表(ADAS-cog)评分和屏气指数(BHI)方面均有统计学意义(P<0.001)。两组的不良反应发生率则无明显差异(P=0.53)。结论相较于单用多奈哌齐,多奈哌齐联合丁苯酞治疗AD的疗效更佳。但由于纳入了少量的单中心研究文献,随访时间短,上述结论仍需大量、高质量的随机对照研究实验加以证实。Objective To evaluate the efficacy of donepezil combined with butylphthalide in the treatment of Alzheimer's disease(AD)through meta-analysis,and to explore its potential mechanism.Methods Computerized searches were conducted in the databases of CNKI,Wanfang,PubMed,International Clinical Trials Registry Platform(ICTRP),and The Cochrane Library from the establishment of the database to March 2023 for literature related to the treatment of AD with Donepezil combined with Butylphthalide(hereinafter referred to as the combined treatment group).Revman 5.4 software was used for meta-analysis.Results In this study,a total of 14 randomized controlled trials were included,with 630 patients in the combined treatment group and 638 patients in the control group(Donepezil alone).The meta-analysis results showed that compared with the control group,the combined treatment group had statistically significant differences in total efficacy,mini-mental state examination(MMSE)score,Alzheimer's disease assessment scale-cognitive subscale(ADAS-cog)score,and breath holding index(BHI)(P<0.001).There was no significant difference in the incidence of adverse reactions between the two groups(P=0.53).Conclusion Compared with donepezil alone,donepezil combined with butylphthalide has better efficacy in the treatment of AD.However,due to the inclusion of a small number of single-center research articles and short follow-up time,the above conclusions still need to be confirmed by large-scale,high-quality randomized controlled trials.

关 键 词：阿尔茨海默病 丁苯酞 多奈哌齐 META分析 

分 类 号：R741[医药卫生—神经病学与精神病学]