丙戊酸镁联合拉莫三嗪在双相情感障碍患者中的应用效果及对WAIS-RC和WMS评分的影响研究  

Study on effects of magnesium valproate combined with lamotrigine in patients with bipolar disorder and its influence on WAIS-RC and WMS score

作　　者：刘蕊 张叶 LIU Rui;ZHANG Ye(Dalian Seventh People's Hospital,Dalian 116086,China)

机构地区：[1]大连市第七人民医院,116086

出　　处：《中国现代药物应用》2024年第6期39-43,共5页Chinese Journal of Modern Drug Application

摘　　要：目的探讨丙戊酸镁联合拉莫三嗪在双相情感障碍患者中的应用效果及对韦氏成人智力量表(WAIS-RC)和韦氏记忆量表(WMS)评分的影响。方法92例双相情感障碍患者,按随机数字表法分为对照组和观察组,各46例。两组均给予常规方法治疗,对照组接受丙戊酸镁治疗,观察组接受丙戊酸镁联合拉莫三嗪治疗。比较两组WAIS-RC与WMS评分、情绪状态、炎性因子[白细胞介素-1(IL-1)、白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)]、生活质量及不良反应发生率。结果两组治疗4周后WAIS-RC中语言智商、智商项目、操作智商评分及WMS中长时记忆、短时记忆、即刻记忆评分均得到提高,且观察组WAIS-RC中语言智商评分(115.28±11.71)分、智商项目评分(113.53±12.32)分、操作智商评分(114.62±15.94)分及WMS中长时记忆评分(44.39±6.82)分、短时记忆评分(59.74±9.48)分、即刻记忆评分(15.26±3.26)分均高于对照组的(109.48±13.23)、(107.53±12.51)、(108.53±8.59)、(40.26±5.06)、(54.56±2.93)、(13.24±2.81)分(P<0.05)。两组治疗4周后杨氏狂躁量表(YMRS)、抑郁自评量表(SDS)评分均得到降低,且观察组YMRS评分(7.51±1.24)分及SDS评分(40.34±4.41)分均低于对照组的(15.69±2.69)、(50.29±5.54)分(P<0.05)。两组治疗前IL-1、IL-10、TNF-α、CRP水平比较无统计学差异(P>0.05);两组治疗4周后IL-1、TNF-α、CRP水平均得到降低,IL-10水平均得到升高,且观察组IL-1、TNF-α、CRP水平均低于对照组,IL-10水平均高于对照组(P<0.05)。两组治疗4周后躯体疼痛、精神健康、活力、社会功能及总体健康评分得到提高,且观察组躯体疼痛评分(89.45±6.81)分、精神健康评分(90.39±6.73)分、活力评分(90.58±7.91)分、社会功能评分(88.68±6.61)分及总体健康评分(91.12±7.39)分均高于对照组的(80.68±5.62)、(82.12±6.02)、(83.25±6.70)、(82.61±5.95)、(80.33±6.41)分(P<0.05)。两组用药期间不Objective To explore the effects of magnesium valproate combined with lamotrigine in patients with bipolar disorder and its influence on Wechsler adult intelligence scale revised in China(WAIS-RC)and Wechsler memory scale(WMS)score.Methods 92 patients with bipolar disorder were divided into a control group and an observation group according to random number table method,with 46 cases in each group.Both groups were given conventional treatment.On this basis,the control group received magnesium valproate treatment,and the observation group received magnesium valproate combined with lamotrigine treatment.Comparison was made on WAIS-RC and WMS scores,emotional state,inflammatory factors[interleukin-1(IL-1),interleukin-10(IL-10),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)],quality of life and incidence of adverse reactions between the two groups.Results After 4 weeks of treatment,the scores of verbal IQ,IQ item,operational IQ in WAIS-RC,scores of long-term memory,short-term memory and immediate memory in WMS were improved in both groups;in the observation group,the verbal IQ score in WAIS-RC was(115.28±11.71)points,the IQ item score was(113.53±12.32)points,the operational IQ score was(114.62±15.94)points,the long-term memory score in WMS was(44.39±6.82)points,the short-term memory score was(59.74±9.48)points,and the immediate memory score was(15.26±3.26)points,which were higher than(109.48±13.23),(107.53±12.51),(108.53±8.59),(40.26±5.06),(54.56±2.93),and(13.24±2.81)points in the control group(P<0.05).After 4 weeks of treatment,the scores of Young's mania rating scale(YMRS)and self-rating depression scale(SDS)decreased in both groups;the observation group had YMRS score of(7.51±1.24)points and SDS score of(40.34±4.41)points,which were lower than(15.69±2.69)and(50.29±5.54)points in the control group(P<0.05).Before treatment,there were no statistical differences in IL-1,IL-10,TNF-αand CRP levels between the two groups(P>0.05).After 4 weeks of treatment,the levels of IL-1,TNF-αand CRP decrea

关 键 词：丙戊酸镁 拉莫三嗪 双相情感障碍 韦氏成人智力量表 韦氏记忆量表 生活质量 

分 类 号：R749.4[医药卫生—神经病学与精神病学]