非侵入性指标对溃疡性结肠炎的诊断意义  

The diagnostic significance of non-invasive indicators for ulcerative colitis

作　　者：关小明[1] 陈锴[2] GUAN Xiao-ming;CHEN Kai(Clinical Laboratory,Foshan Hospital of Traditional Chinese Medicine,Foshan 528000,China)

机构地区：[1]佛山市中医院检验科,528000 [2]佛山市中医院消化内科,528000

出　　处：《中国现代药物应用》2024年第6期75-78,共4页Chinese Journal of Modern Drug Application

摘　　要：目的 研究非侵入性指标在溃疡性结肠炎(UC)诊断中的应用价值。方法 选取66例UC患者为研究组,另选取66例健康检查者为对照组。检测并比较两组血液指标[中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)、中性粒细胞与血小板压积比值(NPR)、单核细胞与淋巴细胞比值(MLR)、总胆红素(TBIL)、间接胆红素(IBIL)、血清淀粉样蛋白A(SAA)]及粪便指标[粪钙卫蛋白(FC)、粪乳铁蛋白(FL)]。结果 研究组NLR(3.54±1.02)、PLR(223.39±45.27)、NPR(15.01±4.28)、SAA(22.60±5.08)mg/L、TBIL(19.03±7.56)μmol/L、IBIL(10.39±3.09)μmol/L、FC(177.24±21.27)μg/g、FL(201.72±32.11)μg/g均高于对照组的(1.54±0.68)、(75.35±22.21)、(8.11±2.99)、(3.89±1.32)mg/L、(15.01±7.31)μmol/L、(7.43±2.81)μmol/L、(32.42±13.71)μg/g、(55.00±17.50)μg/g(P<0.05);研究组MLR与对照组相比无差异(P>0.05)。中度组的NLR(3.99±1.13)、PLR(247.56±80.39)、SAA(33.76±11.04)mg/L、FC(279.48±104.63)μg/g、FL(278.05±47.36)μg/g均高于轻度组的(3.08±1.02)、(199.21±78.25)、(11.43±5.30)mg/L、(75.00±23.14)μg/g、(125.39±31.77)μg/g(P<0.05);中度组NPR、MLR、TBIL、IBIL与轻度组相比无差异(P>0.05)。NLR、PLR、NPR、SAA、TBIL、IBIL、FC、FL是UC发病的影响因素(P<0.05), NLR、SAA、FC是UC严重程度的影响因素(P<0.05)。结论 在诊断UC时使用非侵入性指标,对随时评估治疗效果以及预测疾病复发有一定的帮助。Objective To study the practical value of non-invasive indicators for ulcerative colitis(UC).Methods 66 patients with UC were selected as the study group and 66 healthy subjects were selected as the control group.The blood indicators[neutrophil to lymphocyte ratio(NLR),platelet to lymphocyte ratio(PLR),neutrophil to platelet ratio(NPR),monocyte to lymphocyte ratio(MLR),total bilirubin(TBIL),indirect bilirubin(IBIL),serum amyloid A(SAA)]and fecal indicators[fecal calcarein(FC),fecal lactoferrin(FL)]of the two groups were detected and compared.Results The study group had NLR of(3.54±1.02),PLR of(223.39±45.27),NPR of(15.01±4.28),SAA of(22.60±5.08)mg/L,TBIL of(19.03±7.56)μmol/L,IBIL of(10.39±3.09)μmol/L,FC of(177.24±21.27)μg/g,and FL of(201.72±32.11)μg/g,which were higher than(1.54±0.68),(75.35±22.21),(8.11±2.99),(3.89±1.32)mg/L,(15.01±7.31)μmol/L,(7.43±2.81)μmol/L,(32.42±13.71)μg/g,and(55.00±17.50)μg/g in the control group(P<0.05).There was no difference in MLR between the study group and the control group(P>0.05).The moderate group had NLR of(3.99±1.13),PLR of(247.56±80.39),SAA of(33.76±11.04)mg/L,FC of(279.48±104.63)μg/g,and which were higher than(3.08±1.02),(199.21±78.25),(11.43±5.30)mg/L,(75.00±23.14)μg/g,and(125.39±31.77)μg/g in mild group(P<0.05).There were no differences in NPR,MLR,TBIL and IBIL between moderate group and mild group(P>0.05).NLR,PLR,NPR,SAA,TBIL,IBIL,FC,and FL were the influencing factors for the onset of UC(P<0.05),and NLR,SAA,and FC were the influencing factors for the severity of UC(P<0.05).Conclusion The use of noninvasive indicators in the diagnosis of UC is helpful in assessing treatment effectiveness and predicting disease recurrence at any time.

关 键 词：溃疡性结肠炎 非侵入性指标 诊断 

分 类 号：R574.62[医药卫生—消化系统]