Physical activity and cancer risk:a dose-response analysis for the Global Burden of Disease Study 2019  

作　　者：Xiayao Diao Yudong Ling Yi Zeng Yueqian Wu Chao Guo Yukai Jin Xiaojiang Chen Shoucheng Feng Jianrong Guo Chao Ding Feiyu Diao Zhicheng Du Shanqing Li Haibo Qiu 

机构地区：[1]Department of Thoracic Surgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,P. R. China [2]Department of Gastric Surgery,Sun Yat-sen University Cancer Center,Guangzhou,Guangdong,P. R. China [3]Department of Medical Statistics,School of Public Health,Sun Yat-sen University,Guangzhou,Guangdong,P. R. China [4]Department of General Surgery,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou,Guangdong,P. R. China

出　　处：《Cancer Communications》2023年第11期1229-1243,共15页癌症通讯（英文）

基　　金：supported by the Natural Science Foundation of Guangdong Province(2022A1515012347);the Beijing CSCO research fund(Y-2019Roche-157);the Science and Technology Project of Guangdong(2014A020212331);the National Natural Science Foundation of China(82001672);the National High Level Hospital Clinical Research Funding(2022-PUMCH-B-011).

摘　　要：Objective Adopting a healthy lifestyle,including regular physical activity,is widely believed to decrease cancer risk.This study aimed to quantitatively establish the dose-response relationships between total physical activity and the risk of breast,colon,lung,gastric,and liver cancers.Methods A systematic review and dose-response analysis were conducted using PubMed and Embase from January 1,1980 to March 20,2023.Prospective cohort studies that examined the association between physical activity and the risks of any of the 5 outcomes were included.The search was confined to publications in the English language with a specific focus on human studies.Physical activity is standardized by using the data from US National Health and Nutrition Examination Surveys(NHANES)and the Global Burden of Disease 2019 database.Results A total of 98 studies,involving a combined population of 16,418,361 individuals,were included in the analysis.Among the included studies,57 focused on breast cancer,17 on lung cancer,23 on colon cancer,5 on gastric cancer,and 7 on liver cancer.Overall,elevated levels of physical activity exhibited an inverse correlation with the risk of cancer.The dose-response curve for lung cancer exhibited a non-linear pattern,with the greatest benefit risk reduction observed at 13,200 MET-minutes/week of physical activity,resulting in a 14.7%reduction in risk(relative risk 0.853,uncertainty interval 0.798 to 0.912)compared to the inactive population.In contrast,the dose-response curves for colon,gastric,breast,and liver cancers showed linear associations,indicating that heightened levels of total physical activity were consistently associated with reduced cancer risks.However,the increase in physical activity yielded a smaller risk reduction for colon and gastric cancers compared to breast and liver cancers.Compared to individuals with insufficient activity(total activity level<600 MET-minutes/week),individuals with high levels of activity(≥8,000 MET-minutes/week)experienced a 10.3%(0.897,0.860 to 0.934)risk re

关 键 词：cancer risk dose-response analysis Global Burden of Disease physical activity 

分 类 号：R73[医药卫生—肿瘤]