术前营养/炎症指标与结直肠癌根治术后患者预后的关系  

Correlation of Preoperative Nutritional/Inflammatory Indicators With Prognosis of Colorectal Cancer Patients Underwent Radical Surgery

作　　者：欧歌 何丹玲 谢凯强 葛杰[4,5] OU Ge;HE Danling;XIE Kaiqiang;GE Jie(Department of Pharmacy,Hunan Provincial People′s Hospital(The First Affiliated Hospital of Hunan Normal University),Changsha,410002;Xiangya School of Pharmaceutical Sciences,Central South University,Changsha;Department of Pharmacy,Xiangya Hospital,Central South University,Changsha;Department of Gastrointestinal Surgery,Xiangya Hospital,Central South University,Changsha;National Clinical Research Center for Geriatric Disorders(Xiangya Hospital),Changsha)

机构地区：[1]湖南省人民医院(湖南师范大学第一附属医院)药学部,410002 [2]中南大学湘雅药学院 [3]中南大学湘雅医院药学部 [4]中南大学湘雅医院胃肠外科 [5]国家老年疾病临床医学研究中心(湘雅医院)

出　　处：《胃肠病学》2023年第7期389-396,共8页Chinese Journal of Gastroenterology

基　　金：长沙市自然科学基金(kq2208387)。

摘　　要：背景:消化道肿瘤患者营养状况和炎症指标与预后存在联系。目的:探究术前营养/炎症指标与结直肠癌根治术后患者预后的相关性,并寻找有预后价值的评估指标。方法:纳入2018年4月-2020年12月接受根治性手术的结直肠癌患者,建立患者队列,收集患者基本信息并进行分析,探究术前营养/炎症指标与患者预后的相关性,并筛选出能够预测预后的术前营养/炎症指标。结果:共收集146例患者。单因素Cox比例风险回归分析结果显示肿瘤家族史、TNM分期、CEA、AGR、PLR、SII与生存期显著相关(P<0.05)。多因素分析显示AGR(HR=0.227,95%CI:0.087~0.595;P=0.003)、NLR(HR=2.472,95%CI:1.058~5.778;P=0.037)、PLR(HR=2.692,95%CI:1.162~6.235;P=0.021)和SII(HR=5.237,95%CI:1.857~14.771;P=0.002)与结直肠癌患者生存期相关,其中AGR的预测能力最优。结论:术前AGR、NLR、PLR和SII四项术前营养/炎症指标与结直肠癌根治术后患者预后相关。Background:Nutritional status and inflammatory indicators in patients with gastrointestinal tumors have a significant impact on patient prognosis.Aims:To investigate the association of preoperative nutritional/inflammatory indicators with the prognosis of colorectal cancer patients underwent radical surgery,and to identify valuable prognostic assessment indicators.Methods:Colorectal cancer patients underwent radical surgery from April 2018 to December 2020 were enrolled,and a patient cohort was established.Clinical data were collected,correlation of preoperative nutritional/inflammatory indicators with prognosis were analyzed,and predictive nutritional/inflammatory indicators were screened.Results:A total of 146 patients were collected in this study.The results of Cox proportional hazard regression univariate analysis showed that family history of tumor,TNM staging,CEA,AGR,PLR,and SII were significantly associated with survival(P<0.05).Multivariate analysis revealed that AGR(HR=0.227,95%CI:0.087⁃0.595;P=0.003),NLR(HR=2.472,95%CI:1.058⁃5.778;P=0.037),PLR(HR=2.692,95%CI:1.162⁃6.235;P=0.021)and SII(HR=5.237,95%CI:1.857⁃14.771;P=0.002)were associated with prognosis of colorectal cancer patients,and AGR had the best predictive ability.Conclusions:Four preoperative nutritional/inflammatory indicators,AGR,NLR,PLR,and SII,are associated with prognosis of colorectal cancer patients underwent radical surgery.

关 键 词：结直肠肿瘤 营养指标 炎症指标 预后 

分 类 号：R735.34[医药卫生—肿瘤]