甲钴胺片联合醋酸泼尼松龙治疗周围性面瘫效果及对T淋巴细胞亚群的影响  

Efficacy of Mecobalamine Tablets Combined with Prednisolone Acetate in the Treatment of Peripheral Facial Paralysis and Its Effect on T Lymphocyte Subsets

作　　者：叶斌 邹秀丽 刘廉 YE Bin;ZOU Xiuli;LIU Lian(Department of Otolaryngology,Nanping Second Hospital,Nanping,Fujian Province,354200 China)

机构地区：[1]南平市第二医院耳鼻喉科,福建南平354200

出　　处：《中外医疗》2024年第3期87-90,共4页China & Foreign Medical Treatment

摘　　要：目的探讨甲钴胺片与醋酸泼尼松龙联合治疗周围性面瘫的临床疗效及对T淋巴细胞亚群的影响。方法方便选取2018年3月—2022年12月期间南平市第二医院耳鼻喉科和神经内科收治的130例周围性面瘫患者作为研究对象,以治疗方式不同分组,将患者分为对照组(n=65,采取维生素^(+)醋酸泼尼松龙治疗)及观察组(n=65,对照组基础上加甲钴胺片治疗)。治疗后对比两组患者免疫指标、面神经功能评分以及临床疗效。结果治疗后观察组的改良面瘫评分量表、躯体功能及社会生活功能评分均高于对照组,观察组的CD4^(+)、CD4^(+)/CD8^(+)均高于对照组,差异有统计学意义(P均<0.05);同时观察组的临床有效率(92.31%)高于对照组的临床有效率(80.00%),差异有统计学意义(χ^(2)=4.127,P<0.05)。结论在对周围性面瘫进行治疗时采取甲钴胺片与醋酸泼尼松龙的联合治疗能够有效调节患者的免疫功能、促进患者面神经的恢复,进而达到提高临床效果的目的。Objective To investigate the clinical efficacy of mecobalamine tablets combined with prednisolone acetate in the treatment of peripheral facial paralysis and its influence of T lymphocyte subsets.Methods A total of 130 pa-tients with peripheral facial paralysis admitted to the Department of Otolaryngology and Neurology of Nanping Second Hospital from March 2018 to December 2022 were conveniently selected as study subjects.Patients were divided into control group(n=65,treated with vitamin+prednisolone acetate)and observation group(n=65,treated with mecobalamine tablet on the basis of control group)according to the difference of treatment method.After treatment,the immune indexes,facial nerve function scores and clinical efficacy of the two groups were compared.Results After treatment,Portmann,facial disability index physical function and facial disability index social function scores in observation group were higher than those in the control group,while CD4^(+),CD4^(+)/CD8^(+)in observation group were higher than those in control group,and the differences were statistically significant(all P<0.05).The clinical effective rate of observation group(92.31%)was higher than that of control group(80.00%),and the difference was statistically significant(χ^(2)=4.127,P<0.05).Conclusion In the treatment of peripheral facial paralysis,the combination of mecobalamine tablets and prednisolone acetate can effectively regulate the immune function of patients,promote the recovery of facial nerves,and thus achieve the purpose of improving the clinical effect.

关 键 词：甲钴胺片 醋酸泼尼松龙 周围性面瘫 T淋巴细胞亚群 

分 类 号：R745.12[医药卫生—神经病学与精神病学]