超声多模态检查联合血清Egfl7、VEGF、OPN对肝癌微血管侵犯的诊断价值及预后价值分析  

Diagnostic and Prognostic Values of Multimodal Ultrasound Combined with Serum Egfl7,VEGF and OPN in Microvascular Invasion of Hepatocellular Carcinoma

作　　者：谢永泉 Xie Yong-quan*(Ultrasonic Department of Tingzhou Hospital,Tingzhou 366300,Fujian Province,China)

机构地区：[1]福建省汀州医院超声科,福建汀州366300

出　　处：《罕少疾病杂志》2024年第4期51-53,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的探讨与分析超声多模态检查联合血清表皮生长因子样结构域蛋白7(epidermal growth factor-like domain protein 7,EGFL7)、血管内皮生长因子(vascular endothelial growth factor,VEGF)、骨桥蛋白(osteopontin,OPN)对肝癌微血管侵犯的诊断价值及预后价值。方法2018年2月到2021年5月选择在本院诊治的肝癌患者78例作为研究对象,所有患者都给予超声多模态检查联合血清Egfl7、VEGF、OPN检测,同时给予手术病理检查,判断微血管侵犯状况,随访患者的预后并进行预测价值分析。结果78例患者中检出微血管侵犯阳性28例,占比35.9%。阳性组的肝癌血管分级、血管分布与阴性组对比有明显差异(P<0.05)。阳性组的血清Egfl7、VEGF、OPN含量都明显高于阴性组(P<0.05)。所有患者随访到2022年10月1日,平均随访时间28.47±2.10个月,死亡22例,死亡率为78.6%。多因素Logistic回归分析显示微血管侵犯、血管分级、血管分布与血清Egfl7、VEGF、OPN含量都为影响患者随访死亡的重要因素(P<0.05)。结论肝癌微血管侵犯患者多表现为超声多模态血管分级程度高与混合血流状况,伴随有血清Egfl7、VEGF、OPN的高表达,超声与联合血清Egfl7、VEGF、OPN对肝癌微血管侵犯的诊断预后预测都有很好的价值。Objective To investigate and analysis the diagnostic and prognostic values of multimodal ultrasound combined with serum EGFL7,VEGF,OPN in microvascular invasion of hepatocellular carcinoma.Methods From February 2018 to May 2021,78 cases of patients withhepatocellular carcinoma diagnosed and treated in our hospital were selected as the study subjects.All patients were given ultrasonic multimodal examination combined with serum Egfl7,VEGF and OPN detection.At the same time,surgical and pathological examinations were given to judge the status of microvascular invasion.The prognosis of patients were followed up and predictive value analysis was conducted.Results Microvascular invasion were detected in 28 cases of 78 patients(35.9%).There were significant differences compared between the positive group and the negative group in the vascular classification and distribution ofhepatocellular carcinoma(P<0.05).The levels of serum Egfl7,VEGF and OPN in the positive group were significantly higher than those in the negative group(P<0.05).All patients were followed up to October 1,2022,with an average followup time of 28.47±2.10 months,there were 22 patients of died,with the mortality of 78.6%.Multivariate logistic regression analysis showed that microvascular invasion,vascular classification,vascular distribution and serum Egfl7,VEGF,OPN levels were important factors affected followedup mortality(P<0.05).Conclusion The patients with microvascular invasion of hepatocellular carcinoma mostly showed high ultrasonic multimodal vascular classification and mixed blood flow,accompanied by high expression of serum Egfl7,VEGF,OPN.Ultrasound and combined serum Egfl7,VEGF,OPN have good value in predicting the diagnosis and prognosis of microvascular invasion of hepatocellular carcinoma.

关 键 词：肝癌 微血管侵犯 表皮生长因子样结构域蛋白7 血管内皮生长因子 多模态超声 

分 类 号：R575[医药卫生—消化系统]