Application of ARFI technology to explore the clinical study of Gandou Tang in treating liver fibrosis of wilson's disease with damp-heat accumulation  

作　　者：Han Hui Wang Mei-xia Tao Zhuang Zhang Yanyun Zhang Yu Jiang Zhenzhen Wang Fei Sun Kuo 

机构地区：[1]The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine,Hefei 230031,China [2]The Graduate School of Anhui University of Traditional Chinese Medicine,Hefei 230038,China

出　　处：《Journal of Hainan Medical University》2023年第9期46-51,共6页海南医学院学报（英文版）

基　　金：Training Program for Young Qhuang Scholars[Chinese Medicine Education Letter(2022)No.256];Key Research and Development Program of Anhui Province(No.202204295107020001);Anhui Young Leaders Reserve Talent Project[No.4,Middle Development(2022)];National Natural Science Foundation of China(No.81973825,82104783)。

摘　　要：Objective:Acoustic radiation force impulse(ARFI)was applied to measure Shear wave velocity(SWV)of liver in patients with Wilson's disease(WD).To investigate the relationship between SWV and the serological indexes of liver fibrosis,such as type Ⅳ collagen(CⅣ),hyaluronic acid(HA),type Ⅲ procollagen peptide(PⅢNP),laminin(LN),APRI score(Asparate Aminotransfer to Platelet Ratio Index),and FIB-4 index(FIB-4 index).The clinical efficacy of GandouTang(GDT)in the treatment of liver fibrosis in WD with damp-heat internalization was also observed.Methods:80 cases of WD patients who met the inclusion criteria were randomly divided into the treatment group and the control group,with 40 cases in each group.The control group was treated with Sodium Dimercaptopropylsulfonate(DMPS)and the treatment group was additionally treated with the traditional Chinese medicine GDT.One course for 8 days,a total of 6 courses.The levels of SwV and four serological indicators of liver fibrosis(PⅢNP,HA,CⅣ,LN),APRI score and FIB-4 index were compared before and after treatment.Pearson correlation test was used to analyze the correlation between SWV and HA,CⅣ,LN,PⅢNP,APRI score and FIB-4 index.The effects of GDT on SWV,liver fiber,APRI and FIB-4 were evaluated according to the treatment plan.Results:①The SWV was positively correlated with FIB-4(r=0.83),APRI(r=0.82),HA(r=0.87),CⅣ(r=0.71),LN(r=0.85)and PINP(r=0.77).②Before treatment,there were no significant differences in SWV level,PⅢNP,HA,CⅣ,LN,APRI and FIB-4 levels between two groups(P>0.05).After treatment,the levels of PⅢNP,HA,LN,SWV,APRI and FIB-4 in both groups were significantly decreased(P<0.05,P<0.01),and the levels in the treatment group were lower than those in the control group.There were no significant specific changes in CⅣ level(P>0.05).Conclusion:SWV value can reflect the degree of WD liver fibrosis,and is positively correlated with HA,PⅢNP,CⅣ,LN,FIB-4 index and APRI score.On the basis of the treatment of protecting liver and expelling copper with

关 键 词：Liver fibrosis Hepatolenticular degeneration GandouTang Acoustic pulse radiation force imaging technology Shear wave velocity of liver 

分 类 号：R575.2[医药卫生—消化系统]