Meta-analysis of Traditional Chinese Medicine combined with Ivabradine in the Treatment of Chronic Heart Failure  

作　　者：OUYANG Jia-hui ZHANG Miao DU Tian-yi GAO Zhu-ye LI Li-zhi 

机构地区：[1]Graduate school of Beijing University of Chinese Medicine,Beijing 100029,China [2]School of Chinese Medicine,University of Chinese Medicine,Beijing 100700,China [3]National Clinical Research Center for Chinese Medicine Cardiology,Xiyuan Hospital,China Academy of Chinese Medicine Sciences,Beijing 100091,China

出　　处：《Journal of Hainan Medical University》2023年第9期60-66,共7页海南医学院学报（英文版）

基　　金：National 12th Five-Year Science and Technology Support Plan(No.2013BAI02B01);National Key Science and Technology Project of"Major New Drug Creation"(No.2019ZX09201005-002-006);Beijing TCM Science and Technology Development Fund Project(No.JJ-2020-79);Science and Technology Innovation Project of China Academy of Chinese Medical Sciences(No.CI2021A00920)。

摘　　要：Objective:To systemically evaluate clinical efficacy and safety of traditional Chinese medicine(TCM)combined with ivabradine(IVA)in the treatment of chronic heart failure(CHF).Method:We searched China National Knowledge Infrastructure(CNKI)datebase,Wanfang datebase,Chinese Scientifific Journal Database(VIP)datebase,PubMed,Conchrane Library and EMbase database to enroll the random control trials(RCTs)of TCM combined with IVA treating CHF.Meta-analysis was performed by Review Manager 5.3 software.Results:A total of 10 RCTs involving 960 patients were included.The results of Meta-analysis showed that compared with control group,the experimental group could improve the efficiency of cardiac function improvement[RR=1.19,95%CI(1.12,1.27),P<0.00001],increase left ventricular ejection fraction[MD=4.36,95%CI(2.88,5.83),P<0.0001]and reduce heart rate[MD=-8.21,95%CI(-12.08,-4.34),P<0.00001],the incidence of adverse reactions was similar between two groups[RR=1.00,95%CI(0.62,1.61),P=1.00].Conclusion:Traditional Chinese medicine combined with ivabradine has significant efficacy and good safety in improving cardiac function,improving left ventricular ejection fraction and reducing heart rate in the treatment of chronic heart failure.

关 键 词：Chronic Heart Failure Traditional Chinese Medicine IVABRADINE META-ANALYSIS 

分 类 号：R541.6[医药卫生—心血管疾病] R259[医药卫生—内科学]