疏肝和胃方联合奥美拉唑治疗门诊胃痞病肝胃不和证的效果观察  

Observation on the Effect of Shugan Hewei Formula Combined with Omeprazole in the Treatment of Outpatient Stuffiness of Stomach Disease with Syndrome of Disharmony between Liver and Stomach

作　　者：谢剑晨 XIE Jianchen(Suzhou Xiangcheng People's Hospital,Suzhou 215131,China)

机构地区：[1]苏州市相城人民医院,江苏苏州215131

出　　处：《中外医学研究》2024年第5期6-10,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:研究疏肝和胃方联合奥美拉唑治疗门诊胃痞病肝胃不和证的效果。方法:选取2022年1—12月苏州市相城人民医院门诊收治的206例胃痞病肝胃不和证患者。根据随机数表法将其分为对照组和观察组,各103例。两组均给予常规治疗。对照组采用奥美拉唑治疗,观察组采用疏肝和胃方联合奥美拉唑治疗。比较两组治疗3个月后临床效果,治疗前、治疗3个月后肠胃功能指标、应激指标及不良反应。结果:观察组总有效率为92.23%,高于对照组的77.67%,差异有统计学意义(P<0.05)。治疗3个月后,观察组胃动素(MTL)、胃蛋白酶原Ⅱ(PGⅡ)水平均高于对照组,差异有统计学意义(P<0.05)。治疗3个月后,观察组P物质(SP)水平高于对照组,热休克蛋白(HSP)水平低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:疏肝和胃方联合奥美拉唑治疗门诊胃痞病肝胃不和证效果显著,有利于改善患者的肠胃功能与应激指标,且安全。Objective:To study the effect of Shugan Hewei Formula combined with Omeprazole in the treatment of outpatient stuffiness of stomach disease with syndrome of disharmony between liver and stomach.Method:A total of 206 patients with stuffiness of stomach disease with syndrome of disharmony between liver and stomach were selected from the Outpatient Department of Suzhou Xiangcheng People's Hospital from January to December 2022.They were divided into control group and observation group according to random number table method,103 cases in each group.Both groups were given conventional treatment.The control group was treated with Omeprazole,and the observation group was treated with Shugan Hewei Formula combined with Omeprazole.The clinical efficacy after 3 months of treatment,gastrointestinal function indexes,stress indexes before and after 3 months of treatment and adverse reactions were compared between the two groups.Result:The total effective rate of the observation group was 92.23%,which was higher than 77.67% of the control group,and the difference was statistically significant(P<0.05).After 3 months of treatment,the levels of motilin(MTL)and pepsinogen Ⅱ(PGⅡ)in observation group were higher than those in control group,and the differences were statistically significant(P<0.05).After 3 months of treatment,the substance P(SP)level in the observation group was higher than that in the control group,and the heat shock protein(HSP)level was lower than that in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The effect of Shugan Hewei Formula combined with Omeprazole in the treatment of outpatient stuffiness of stomach disease with syndrome of disharmony between liver and stomach is significant,which is beneficial to improve the gastrointestinal function and stress indexes of patients,and is safe.

关 键 词：疏肝和胃方 奥美拉唑肠溶片 肠胃功能 

分 类 号：R573[医药卫生—消化系统]