吲哚布芬与氯吡格雷治疗缺血性心脑血管疾病合并上消化道出血患者的效果与安全性  

Efficacy and Safety of Indobufen and Clopidogrel in Patients with Ischemic Cardiovascular and Cerebrovascular Diseases Combined with Upper Gastrointestinal Hemorrhage

作　　者：郑烁[1] 许联 赵楚英 刘渚 唐小荣[1] ZHENG Shuo;XU Lian;ZHAO Chuying;LIU Zhu;TANG Xiaorong(Chaozhou Central Hospital,Chaozhou 521000,China;不详)

机构地区：[1]潮州市中心医院,广东潮州521000

出　　处：《中外医学研究》2024年第7期50-53,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:分析吲哚布芬与氯吡格雷在治疗缺血性心脑血管疾病合并上消化道出血患者中的效果与安全性。方法:选取2021年3月—2023年4月潮州市中心医院收治的60例缺血性心脑血管疾病合并上消化道出血患者,随机将其分为两组,各30例。对照组实施氯吡格雷治疗,观察组实施吲哚布芬治疗,对比两组临床疗效、炎症因子、不良反应情况。结果:干预后,观察组的总有效率为96.67%(29/30),高于对照组的76.67%(23/30),差异有统计学意义(P<0.05)。干预后,观察组hs-CRP、PCT水平明显低于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率6.67%(2/30),低于对照组的26.67%(8/30),差异有统计学意义(P<0.05)。结论:与氯吡格雷相比,吲哚布芬在治疗缺血性心脑血管疾病合并上消化道出血患者中具有良好的临床效果,能有效改善炎症因子水平,降低不良反应发生率,安全性好。Objective:To analyze the effect and safety of Indobufen and Clopidogrel in patients with ischemic cardiovascular and cerebrovascular disease combined with upper gastrointestinal hemorrhage.Method:Sixty patients with ischemic cardiovascular and cerebrovascular diseases combined with upper gastrointestinal hemorrhage admitted to Chaozhou Central Hospital from March 2021 to April 2023 were selected,and they were randomly divided into two groups,30 cases in each group.The control group treated with Clopidogrel and the observation group treated with Indobufen.The clinical efficacy,inflammatory factors and adverse reactions of the two groups were compared.Result:After the intervention,the overall response rate in the observation group was 96.67%(29/30),which was higher than 76.67%(23/30)in the control group,the difference was statistically significant(P<0.05).After the intervention,the hypersensitive C-reactive protein(hs-CRP),procalcitonin(PCT)in the observation group were significantly lower than those in the control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 6.67%(2/30),which was lower than 26.67%(8/30)in the control group,the difference was statistically significant(P<0.05).Conclusion:Compared with Clopidogrel,Indobufen has good efficacy in patients with ischemic cardiovascular and cerebrovascular diseases combined with upper gastrointestinal hemorrhage,effectively improves the level of inflammatory factors and reduces the incidence of adverse reactions,has better safety.

关 键 词：吲哚布芬 氯吡格雷 缺血性心脑血管疾病 上消化道出血 安全性 

分 类 号：R743[医药卫生—神经病学与精神病学] R54[医药卫生—临床医学] R573.2