雷珠单抗预注射后再行玻璃体切割术治疗DR伴NVG患者的效果  

Effect of Pre-injection of Ranibizumab Followed by Pars-plana Vitrectomy in the Treatment of DR patients with NVG

作　　者：黄晓丽 陆水 陈甜甜 HUANG Xiaoli;LU Shui;CHEN Tiantian(Affiliated Central Hospital of Jiangnan University,Wuxi 214002,China;不详)

机构地区：[1]江南大学附属中心医院,江苏无锡214002

出　　处：《中外医学研究》2024年第7期124-127,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨雷珠单抗预注射后再行玻璃体切割术(PPV)治疗糖尿病视网膜病变(DR)伴新生血管性青光眼(NVG)患者的效果。方法:选取2020年6月—2023年6月于江南大学附属中心医院治疗的50例DR伴NVG患者作为研究对象,按随机数表法分为仅行PPV组(以下简称为PPV组,24例24眼)和雷珠单抗预注射后再行PPV组(以下简称为联合单抗组,26例26眼)。比较两组治疗前、术后3个月眼部情况、血清学指标变化,并观察两组术后并发症发生情况。结果:术后3个月,两组眼部情况、血清学指标较治疗前均改善,且联合单抗组眼压、黄斑中心凹厚度(CMT)、血管内皮生成因子(VEGF)与胰岛素样生长因子-1(IGF-1)水平低于PPV组,最佳矫正视力(BCVA)高于PPV组,差异有统计学意义(P<0.05)。联合单抗组术后并发症发生率与PPV组比较,差异无统计学意义(P>0.05)。结论:雷珠单抗预注射后再行PPV可有效降低眼压,消除黄斑水肿,促进患者术后视功能恢复,降低VEGF、IGF-1水平,且未增加并发症发生率。Objective:To investigate the effect of pre-injection of Ranibizumab followed by pars-plana vitrectomy(PPV)in the Treatment of diabetic retinopathy(DR)patients with neovascular glaucoma(NVG).Method:Fifty DR patients with NVG who treated in Affiliated Central Hospital of Jiangnan University from June 2020 to June 2023 were selected as the study objects,and they were divided into the PPV-only group(short for the PPV group,24 cases with 24 eyes)and the pre-injection of Ranibizumab followed by PPV(short for the combination monoclonal antibody group,26 cases with 26 eyes)according to the method of table of random digit.The changes of ocular condition and serological indexes before treatment and 3 months after operation were compared between two groups,and the postoperative complications of two groups were observed.Result:At 3 months after operation,the ocular condition and serological indexes of two groups were improved compared with those before treatment,and the intraocular pressure,central macular thickness(CMT),vascular endothelial growth factor(VEGF)and insulin-like growth factor-1(IGF-1)levels in the combined monoclonal antibody group were lower than those in the PPV group,and the best corrected visual acuity(BCVA)was higher than that in the PPV group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of postoperative complications between the combined monoclonal antibody group and the PPV group(P>0.05).Conclusion:Pre-injection of Ranibizumab followed by PPV can effectively reduce intraocular pressure,eliminate macular edema,promote the recovery of patients'postoperative visual function,and reduce the levels of VEGF and IGF-1,with high safety.

关 键 词：雷珠单抗 玻璃体切割术 糖尿病视网膜病变 新生血管性青光眼 

分 类 号：R779.6[医药卫生—眼科] R587.2[医药卫生—临床医学]