刺五加脑灵合剂对肠易激综合征患者胃肠症状及炎症因子水平的影响  

Effects of Ciwujia Naoling Mixture on Gastrointestinal Symptoms and Inflammatory Factors in Patients with Irritable Bowel Syndrome

作　　者：陆振华 LU Zhenhua(Heilongjiang Academy of Traditional Chinese Medicine Sciences,Harbin 150036,China)

机构地区：[1]黑龙江省中医药科学院,黑龙江哈尔滨150036

出　　处：《中外医学研究》2024年第8期21-25,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:研究刺五加脑灵合剂对肠易激综合征(IBS)患者胃肠症状及炎症因子水平的影响。方法:选取2021年2月—2023年2月黑龙江省中医药科学院收治的150例IBS患者作为研究对象。根据电脑编号随机法分为研究组及参考组,各75例。参考组予以匹维溴铵治疗,研究组在参考组的基础上增用刺五加脑灵合剂治疗。比较两组胃肠症状评分、血清炎症因子水平、肠道菌群含量及脑肠肽指标水平。结果:治疗4周后,两组各项胃肠症状评分均低于治疗前,且研究组低于参考组,差异有统计学意义(P<0.05)。治疗4周后,两组血清炎症因子水平均低于治疗前,且研究组低于参考组,差异有统计学意义(P<0.05)。治疗4周后,两组乳酸杆菌、双歧杆菌含量均高于治疗前,肠杆菌含量低于治疗前,且研究组乳酸杆菌、双歧杆菌含量高于参考组,肠杆菌含量低于参考组,差异有统计学意义(P<0.05)。治疗4周后,两组脑肠肽指标均低于治疗前,且研究组低于参考组,差异有统计学意义(P<0.05)。结论:刺五加脑灵合剂对IBS患者胃肠症状及炎症因子水平均有改善作用,且能促进肠道菌群及脑肠肽的恢复。Objective:To study the effects of Ciwujia Naoling Mixture on gastrointestinal symptoms and inflammatory factors in patients with irritable bowel syndrome(IBS).Method:A total of 150 patients with IBS admitted to Heilongjiang Academy of Traditional Chinese Medicine Sciences from February 2021 to February 2023 were selected as the study objects.They were divided into study group and reference group according to computer numbering random method,with 75 cases in each group.The reference group was treated with Pinaverium Bromide,and the study group was treated with Ciwujia Naoling Mixture on the basis of the reference group.The score of gastrointestinal symptoms,the level of serum inflammatory factors,the content of intestinal flora and the level of brain intestinal peptide indexes were compared between the two groups.Result:After 4 weeks of treatment,the scores of gastrointestinal symptoms in both groups were lower than those before treatment,and the study group were lower than those in the reference group,the differences were statistically significant(P<0.05).After 4 weeks of treatment,the levels of serum inflammatory factors in both groups were lower than those before treatment,and those in the study group were lower than those in the reference group,the differences were statistically significant(P<0.05).After 4 weeks of treatment,the contents of Lactobacillus and Bifidobacterium in two groups were higher than those before treatment,and the contents of Enterobacterium were lower than those before treatment,and the contents of Lactobacillus and Bifidobacterium in study group were higher than those in reference group,and the contents of Enterobacterium were lower than those in reference group,the differences were statistically significant(P<0.05).After 4 weeks of treatment,the brain intestinal peptide indexes in both groups were lower than those before treatment,and those in the study group were lower than those in the reference group,the differences were statistically significant(P<0.05).Conclusion:Ciwujia Naoling Mi

关 键 词：肠易激综合征 刺五加脑灵合剂 胃肠症状 炎症因子 脑肠肽 肠道菌群 

分 类 号：R574.4[医药卫生—消化系统]