甘油三酯-葡萄糖指数对2型糖尿病患者发生NAFLD的预测价值  

Predictive value of triglyceride glucose index for NAFLD in patients with type 2 diabetes mellitus

作　　者：赵永晓 王艳丽 苏江华[2] 王哲[3] 刘娜[1] ZHAO Yongxiao;WANG Yanli;SU Jianghua;WANG Zhe;LIU Na(Department of Gastroenterology,Shijiazhuang Second Hospital,Shijiazhuang 050051,Hebei,China;Hospital Administration Office,Shijiazhuang Second Hospital,Shijiazhuang 050051,Hebei,China;Department of Laboratory,Shijiazhuang Second Hospital,Shijiazhuang 050051,Hebei,China)

机构地区：[1]石家庄市第二医院消化内科,河北石家庄050051 [2]石家庄市第二医院院办公室,河北石家庄050051 [3]石家庄市第二医院检验科,河北石家庄050051

出　　处：《中南医学科学杂志》2024年第2期251-253,264,共4页Medical Science Journal of Central South China

基　　金：河北省医学科学研究重点课题(20201349)。

摘　　要：目的探究甘油三酯-葡萄糖指数(TyG)对2型糖尿病(T2DM)患者发生非酒精性脂肪肝(NAFLD)的预测价值。方法选取T2DM患者306例,根据患者TyG四分位数分为Q1组(n=78)、Q2组(n=55)、Q3组(n=89)和Q4组(n=84),比较患者一般资料和生化指标。随访2年后进行肝脏彩超检查,比较各组NAFLD发生情况,分析T2DM患者发生NAFLD的危险因素,以及TyG对发生NAFLD的预测价值。结果由Q1组至Q4组,患者血清高密度脂蛋白胆固醇逐渐降低,血压、空腹血糖、谷草转氨酶、谷丙转氨酶、谷氨酰转肽酶、尿酸、低密度脂蛋白胆固醇、总胆固醇、甘油三酯、糖化血红蛋白、TyG和NAFLD发生率逐渐升高(P<0.05)。Logistic回归分析显示,TyG越高NAFLD发病风险越高(P<0.05)。TyG对T2DM患者发生NAFLD具有良好的预测价值(P<0.05)。结论TyG可有效预测T2DM患者发生NAFLD,适宜在临床推广应用。Aim To explore the predictive value of triglyceride glucose index(TyG)on nonalcoholic fatty liver disease(NAFLD)in patients with type 2 diabetes mellitus(T2DM).Methods 306 patients with T2DM were selected and divided into Q1 group(n=78),Q2 group(n=55),Q3 group(n=89)and Q4 group(n=84)according to the TyG quartile.The general data and biochemical indexes of patients were compared.After 2 years of follow-up,liver color doppler ultrasound was performed compare the incidence of NAFLD among different groups,analyze the risk factors for NAFLD in T2DM patients,and evaluate the predictive value of TyG for NAFLD occurrence.Results From group Q1 to group Q4,the patients serum high density lipoprotein cholesterol gradually decreased,and the incidence of blood pressure,fasting blood glucose,glutamic-oxaloacetic transaminase,glutamic-pyruvic transaminase,γ-glutamyl transpeptidase,uric acid,low density lipoprotein cholesterol,total cholesterol,triglycerides,glycosylated hemoglobin,TyG and NAFLD gradually increased(P<0.05).Logistic regression analysis showed that the higher TyG was associated with the higher the risk of NAFLD(P<0.05).TyG has a good predictive value for NAFLD in T2DM patients(P<0.05).Conclusion TyG can effectively predict the occurrence of NAFLD in T2DM patients,which is suitable for clinical application.

关 键 词：甘油三酯-葡萄糖指数 2型糖尿病 非酒精性脂肪肝 预测 

分 类 号：R575[医药卫生—消化系统]