CoFe_(2)O_(4) decorated graphene/C_(18)-functionalized mesoporous silica nanocomposites prepared for magnetic enrichment and electrochemical detection of promethazine in beef  

作　　者：Xingdong Yang Shi-Ming Ying Sen Zhang Jinxia Dai Wei Gao Tian-Qi Wang Jun-Qin Qiao Hong-Zhen Lian Li Mao 

机构地区：[1]State Key Laboratory of Analytical Chemistry for Life Science,School of Chemistry&Chemical Engineering and Centre of Materials Analysis,Nanjing University,Nanjing 210023,China [2]Ministry of Education(MOE)Key Laboratory of Modern Toxicology,School of Public Health,Nanjing Medical University,Nanjing 211166,China

出　　处：《Chinese Chemical Letters》2024年第3期208-213,共6页中国化学快报（英文版）

基　　金：supported by the National Key R&D Program of China(No.2019YFC1605400);the National Natural Science Foundation of China(Nos.21874065 and 22176085)。

摘　　要：Promethazine(PHZ)is used as a sedative in veterinary medicine,and its residue can threaten the health of human.The electrochemical detection of PHZ is suitable method for application in the field.However,the traditional electroanalysis is difficult to perform directly in meat samples due to matrix interference.This work integrates magnetic solid-phase extraction and differential pulse voltammetry for highly sensitive and selective determination of PHZ in beef and beef liver for the first time.CoFe_(2)O_(4)/graphene coated with C_(18)-functionalized mesoporous silica(MG@mSiO_(2)-C_(18))is synthesized as dispersed magnetic adsorbent to extract PHZ.Magnetic glassy carbon electrode modified with nitrogen-doped hollow carbon microspheres(HCM)attracts the MG@mSiO_(2)-C_(18)with PHZ,and directly detects the PHZ without elution procedure.MG@mSiO_(2)-C_(18)can separate PHZ to avoid the interference of impurities on following detection,and also concentrate PHZ on magnetic electrode.Additionally,the electrode modification with HCM can amplify the electrochemical signal of PHZ.Finally,the integrated PHZ determination method exhibits a wide linear range from 0.08μmol/L to 300μmol/L with a low limit of detection of 9.8 nmol/L.The beef sample analysis presents excellent recovery,demonstrating that this protocol is promising for the rapid and onsite detection of PHZ in real meat samples。

关 键 词：Promethazine(PHZ) Drug residue Magnetic solid phase extraction Electrochemical detection BEEF 

分 类 号：TS251.52[轻工技术与工程—农产品加工及贮藏工程] O657.1[轻工技术与工程—食品科学与工程]