Synthesis of photostable near-infrared sulfone-rhodamines for photoacoustic imaging-guided photothermal therapy  

作　　者：Huiyu Si Dongjuan Wang Xianfa Du Xin Zhou 

机构地区：[1]Department of Chemistry,College of Chemistry and Chemical Engineering,Qingdao University,Qingdao 266071,China [2]Department of Orthopedics,the Affiliated Hospital of Qingdao University,Qingdao 266071,China

出　　处：《Chinese Chemical Letters》2024年第3期369-372,共4页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(Nos.21762045,21911540466);Shandong Provincial Natural Science Foundation(No.ZR2019YQ12);China Postdoctoral Science Foundation(No.219M652306);Taishan Scholar Project(No.tsqn201812049)for supporting this work。

摘　　要：Photothermal therapy(PTT)is a cutting-edge cancer treatment that can kill cancer cells in hypoxic environments without relying on oxygen.Seeking of the ideal photothermal agents with a high absorption coefficient in the near-infrared region,and a high excellent photothermal conversion efficiency is of great significance.Sulfone-Rhodanmine dye has showed an impressive absorption wavelength over 700 nm,but suffered from a stability issue.In this study,we synthesized five sulfone rhodamines and investigated the substitution effects on stability.SO_(2)R2 showed high stability and strong absorbance at 714 nm with an excellent photothermal conversion efficiency of 53.06%,making it suitable for accurate photoacoustic imaging-guided photothermal therapy in vivo.

关 键 词：Photothermal therapy Sulfone rhodamine NEAR-INFRARED PHOTOACOUSTIC Imaging 

分 类 号：R730.5[医药卫生—肿瘤] O657.3[医药卫生—临床医学]