小胶质细胞在抑郁症发病机制中的作用  

Effects of microglia in the pathogenesis of major depressive disorder

作　　者：杨艳杰[1] 张计丽 卜天一 乔可欣 邱晓惠[1] 乔正学[1] 王雨[1] 陈宇[1] 万博文 徐梓航 Yang Yanjie;Zhang Jili;Bu Tianyi;Qiao Kexin;Qiu Xiaohui;Qiao Zhengxue;Wang Yu;Chen Yu;Wan Bowen;Xu Zihang(Psychology and Health Management Center,Harbin Medical University,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学心理科学与健康管理中心,哈尔滨150081

出　　处：《中华行为医学与脑科学杂志》2024年第3期278-283,共6页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金(81773536)。

摘　　要：抑郁症已成为一个日益严重的公共健康问题,其发病率和致残率均较高,常与多种心理健康问题和躯体疾病共存,对患者的生活质量造成了显著的负面影响。在临床实践中,抑郁症被认为是一种具有异质性的疾病,病理机制的复杂性和治疗反应的差异性导致其缺乏明确的治疗靶标,进而使得治疗过程愈加复杂。近年来,随着神经科学的不断发展,研究揭示了小胶质细胞在抑郁症的发病机制中扮演着至关重要的角色。作为大脑中主要的免疫细胞,小胶质细胞在抑郁症发病机制中不仅涉及神经炎性反应的调节,还在神经发生以及神经元调控等方面发挥着关键作用,本文主要探讨了小胶质细胞在抑郁症病理生理学机制中的作用,旨在为小胶质细胞作为抑郁症潜在治疗靶点提供理论基础。Major depressive disorder(MDD)has become an increasingly serious public health issue,characterized by high incidence and high disability rates.It often coexists with other mental health problems and physical diseases,with a significant negative impact on patients'quality of life.In clinical practice,MDD is considered a heterogeneous disease.The complexity of the pathological mechanisms and the variability in treatment responses lead to a lack of clear therapeutic targets,which complicates the treatment process.In recent years,with advancements in neuroscience,the crucial role of microglia in the pathogenesis of MDD has been revealed.As the main immune cells in the brain,microglia are not only involved in the regulation of neuroinflammation but also play important roles in neurogenesis and neuronal regulation in MDD.This article mainly discusses the role of microglia in the pathophysiological mechanisms of MDD,aiming to provide a theoretical basis for microglia as a potential target for the treatment of MDD.

关 键 词：抑郁症 小胶质细胞 神经元 神经炎性反应 

分 类 号：R749.4[医药卫生—神经病学与精神病学]