急性胰腺炎患者血清VEGF、IL-6及血浆D-D水平变化及其与病情严重程度的相关性  

Changes of levels of serum VEGF,IL-6,plasma D-D in patients with acute pancreatitis and their correlation with the severity of the disease

作　　者：徐娇阳 张林 马春燕 Xu Jiaoyang;Zhang Lin;Ma Chunyan(Department of Clinical Laboratory,Kaifeng Central Hospital,Kaifeng 475000,China)

机构地区：[1]开封市中心医院检验科,开封475000

出　　处：《中国实用医刊》2024年第2期34-37,共4页Chinese Journal of Practical Medicine

摘　　要：目的探究急性胰腺炎(AP)患者血清血管内皮生长因子(VEGF)、白细胞介素-6(IL-6)、血浆D-二聚体(D-D)水平变化,并分析其与病情严重程度的相关性。方法抽取2021年6月至2022年12月开封市中心医院收治的86例AP患者为研究对象(设为研究组),其中轻中度者61例,重度者25例;另抽取同期入院排除胰腺炎的胃肠炎患者86例作为对照组。比较对照组与研究组血清VEGF、IL-6及血浆D-D水平。比较研究组不同病情程度患者血清VEGF及IL-6水平、血浆D-D水平、急性胰腺炎严重程度床边指数(BISAP)、Ranson评分。采用Pearson分析研究血浆D-D及血清VEGF、IL-6水平与BISAP评分、Ranson评分、病情程度的相关性。绘制受试者工作特征曲线评价血清VEGF、IL-6及血浆D-D水平对AP病情程度的诊断价值。结果研究组血浆D-D及血清VEGF、IL-6水平高于对照组(P<0.05)。研究组重度患者血浆D-D及血清VEGF、IL-6水平高于轻中度患者(P<0.05);重度患者BISAP评分、Ranson评分高于轻中度患者(P<0.05)。Pearson相关性分析结果显示,D-D、VEGF、IL-6水平与BISAP评分、Ranson评分、病情程度呈正相关(P<0.05)。受试者工作特征曲线结果显示,D-D、VEGF、IL-6联合诊断AP病情程度的曲线下面积(AUC)大于单项指标诊断(P<0.05),且与BISAP评分、Ranson评分诊断的AUC比较差异未见统计学意义(P>0.05)。结论AP患者血清VEGF、IL-6及血浆D-D水平升高,且与病情严重程度密切相关。联合检测其水平对重度AP具有一定诊断价值。Objective To investigate the changes of levels of serum vascular endothelial growth factor(VEGF),interleukin-6(IL-6)and plasma D-dimer(D-D)in patients with acute pancreatitis(AP),and analyze the correlation of them with the severity of the disease.Methods Eighty-six patients with AP admitted to Kaifeng Central Hospital from June 2021 to December 2022 were selected as study objects(as the study group).Among them,61 cases were classified as mild to moderate,while 25 cases were classified as severe.Additionally,86 patients with gastroenteritis who were admitted to the hospital during the same period were selected as control group,excluding pancreatitis cases.The levels of serum VEGF,IL-6 and plasma D-D were compared between the control group and the study group.The levels of serum VEGF,IL-6 and plasma D-D,bedside index of acute pancreatitis severity(BISAP)score,and Ranson score were compared among patients with different degrees of disease in the study group.Pearson analysis was used to analyze correlation of levels of serum VEGF,IL-6 and plasma D-D with BISAP score,Ranson score and disease severity.The diagnostic value of serum VEGF,IL-6 and plasma D-D levels for the degree of AP condition was evaluated using the receiver operating characteristic curve.Results Levels of serum VEGF,IL-6 and plasma D-D in the study group were higher than those in the control group(P<0.05).The levels of serum VEGF,IL-6 and plasma D-D in severe cases were higher than those in mild-to-moderate cases in the study group(P<0.05).Compared with mild-to-moderate cases,severe cases had higher BISAP score and higher Ranson score(P<0.05).Results of pearson analysis showed that levels of D-D,VEGF and IL-6 are positively correlated with BISAP score,Ranson score and disease severity(P<0.05).Results of receiver operating characteristic curve showed that,area under the curve(AUC)of combination of D-D,VEGF and IL-6 was greater than those of the three single indicators in diagnosing disease severity of AP,and it had no significant difference with AUC o

关 键 词：急性胰腺炎 血管内皮生长因子 D-二聚体 白细胞介素-6 

分 类 号：R576[医药卫生—消化系统]