Hippo-YAP/TAZ signaling in breast cancer:Reciprocal regulation of microRNAs and implications in precision medicine  

作　　者：Farzad Sadri Seyede fatemeh Hosseini Zohreh Rezaei Mohammad Fereidouni 

机构地区：[1]Student Research Committee,Birjand University of Medical Sciences,Birjand 9717853577,Iran [2]Tabas School of Nursing,Birjand University of Medical Sciences,Birjand 9717853577,Iran [3]Department of Biology,University of Sistan and Baluchestan,Zahedan 9816745785,Iran [4]Cellular and Molecular Research Center,Birjand University of Medical Sciences,Birjand 9717853577,Iran

出　　处：《Genes & Diseases》2024年第2期760-771,共12页基因与疾病（英文）

摘　　要：Breast cancer is a molecularly heterogeneous disease and the most common female malignancy.In recent years,therapy approaches have evolved to accommodate molecular diversity,with a focus on more biologically based therapies to minimize negative consequences.To regulate cell fate in human breast cells,the Hippo signaling pathway has been associated with the alpha subtype of estrogen receptors.This pathway regulates tissue size,regeneration,and healing,as well as the survival of tissue-specific stem cells,proliferation,and apoptosis in a variety of organs,allowing for cell differentiation.Hippo signaling is mediated by the kinases MST1,MST2,LATS1,and LATS2,as well as the adaptor proteins SAV1 and MOB.These kinases phosphorylate the downstream effectors of the Hippo pathway,yes-associated protein(YAP),and transcriptional coactivator with PDZ-binding motif(TAZ),suppressing the expression of their downstream target genes.The Hippo signaling pathway kinase cascade plays a significant role in all cancers.Understanding the principles of this kinase cascade would prevent the occurrence of breast cancer.In recent years,small noncoding RNAs,or microRNAs,have been implicated in the development of several malignancies,including breast cancer.The interconnections between miRNAs and Hippo signaling pathway core proteins in the breast,on the other hand,remain poorly understood.In this review,we focused on highlighting the Hippo signaling system,its key parts,its importance in breast cancer,and its regulation by miRNAs and other related pathways.

关 键 词：Breast cancer Hippo signaling Large tumor suppressor kinase 1 MICRORNAS PDZ-binding motif Yes-associated protein 

分 类 号：R737.9[医药卫生—肿瘤]