前列腺小细胞癌伴膀胱高级别浸润性尿路上皮癌并小细胞癌1例报告  

Small cell prostate carcinoma and high-grade invasive urothelial carcinoma of the bladder combined with small cell bladder carcinoma:a case report

作　　者：李勋钢[1] 张文圣[1] 邓新喜[1] 乐志文 曾加 Li Xungang;Zhang Wensheng;Deng Xinxi;Le Zhiwen;Zeng Jia(Department of Urology,The First People's Hospital of Jiujiang City of Jiangxi Province,Jiujiang 332000,China)

机构地区：[1]江西省九江市第一人民医院泌尿外科,九江332000

出　　处：《中华泌尿外科杂志》2024年第3期225-226,共2页Chinese Journal of Urology

摘　　要：前列腺小细胞癌是一种罕见的高度恶性泌尿系统肿瘤,前列腺小细胞癌伴膀胱癌的发病率更低。本文报道1例,患者行超声引导下经直肠前列腺穿刺活检术+经尿道膀胱肿瘤电切术,术后病理及免疫组化染色检查提示前列腺小细胞癌伴膀胱高级别浸润性尿路上皮癌并小细胞癌。患者采用膀胱局部灌注化疗,并予依托泊苷+洛铂全身化疗6个疗程联合特瑞普利单抗免疫治疗。术后随访12个月,复查前列腺MRI、膀胱镜及前列腺特异性抗原,前列腺、精囊腺病变较治疗前缩小,PSA明显降低,膀胱未见肿块。Small cell carcinoma of the prostate is a rare and highly malignant tumor of the urinary system.It is less common for prostate small cell carcinoma coexisting with bladder carcinoma.One such case was reported in this paper.The patient underwent ultrasound-guided transrectal prostate biopsy,and transurethral bladder endoscopy+bladder tumor electric resection.Postoperative pathology and immunohistochemistry showed prostate small cell carcinoma accompanied by high-grade invasive urothelial carcinoma of the bladder and small cell carcinoma.The patient underwent local bladder perfusion chemotherapy,relying on etoposide plus lobaplatin systemic chemotherapy and toripalimab immunotherapy.Prostate MRI,cystoscopy,and prostate-specific antigen(PSA)were performed 12 months after operation.The size of the lesions in the prostate and seminal vesicles had decreased,and there was a significant reduction in PSA levels.Additionally,no masses were detected in the bladder.

关 键 词：癌 前列腺小细胞癌 膀胱小细胞癌 膀胱尿路上皮癌 免疫治疗 

分 类 号：R737.25[医药卫生—肿瘤] R737.14[医药卫生—临床医学]