低氧与急性髓系白血病细胞氧感受通路的相关性  

Correlation between hypoxia and the oxygen sensing pathway in acute myeloid leukemia cells

作　　者：王婷 李文倩[2] 解友邦[2] Wang Ting;Li Wenqian;Xie Youbang(Graduate School of Qinghai University,Xining 810016,China;Department of Hematology,Qinghai Provincial People's Hospital,Xining 810000,China)

机构地区：[1]青海大学研究生院,西宁810016 [2]青海省人民医院血液科,西宁810000

出　　处：《国际肿瘤学杂志》2023年第8期503-507,共5页Journal of International Oncology

基　　金：国家血液系统疾病临床医学研究中心转化研究课题(2021WWB04);青海省血液系统疾病临床研究中心项目(2021-SF-136)。

摘　　要：低氧是血液系统恶性肿瘤微环境的显著特征之一, 低氧微环境可以促进肿瘤细胞转移和浸润, 是导致治疗耐受的关键因素之一, 也是对抗肿瘤免疫反应产生抵抗的重要因素。在急性髓系白血病(AML)中, 细胞的氧感受通路是一种重要的信号转导途径, 它参与了细胞对低氧环境的应答, 并能够调节细胞的代谢、生长和存活等生物学过程。从低氧对白血病细胞氧感受通路的影响因素入手, 以低氧诱导的细胞适应机制为靶点, 探寻低氧环境下靶向治疗血液系统恶性肿瘤的新方向, 可为治疗AML提供新思路及理论支持。Hypoxia is one of the significant characteristics of the microenvironment of malignant tumors in the blood system.Hypoxic microenvironment can promote the metastasis and infiltration of tumor cells,which is one of the key factors leading to treatment tolerance,and also an important factor for resistance against tumor immune response.In acute myeloid leukemia(AML),the cellular oxygen sensing pathway is an important signaling transduction pathway that participates in the cell′s response to hypoxic environments and can regulate biological processes such as metabolism,growth,and survival.Starting from how hypoxia affects the oxygen sensing pathway of leukemia cells,and targeting the cell adaptation mechanism induced by hypoxia,exploring new directions for targeted treatment of hematological malignancies in hypoxic environments can provide new ideas and theoretical support for the treatment of AML.

关 键 词：低氧 急性髓系白血病 靶向治疗 

分 类 号：R733.71[医药卫生—肿瘤]