盐酸美金刚治疗放射性认知功能障碍及其与维生素联合应用的研究进展  

Research progress of memantine hydrochloride in the treatment of radiation-induced cognitive dysfunction and its combined application with vitamins

作　　者：王瑾[1] 李若阳 赵雪巍 李辉 周志国[5] 赵静霞[6] Wang Jin;Li Ruoyang;Zhao Xuewei;Li Hui;Zhou Zhiguo;Zhao Jingxia(Graduate School of Hebei Medical University,Shijiazhuang 050011,China;Breast Center,Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,China;Department of Pharmacy,Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,China;Department of Neurosurgery,Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,China;Department of Radiotherapy,Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,China;Department of Neurology,Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,China)

机构地区：[1]河北医科大学研究生院,石家庄050011 [2]河北医科大学第四医院乳腺中心,石家庄050011 [3]河北医科大学第四医院药学部,石家庄050011 [4]河北医科大学第四医院神经外科,石家庄050011 [5]河北医科大学第四医院放疗科,石家庄050011 [6]河北医科大学第四医院神经内科,石家庄050011

出　　处：《国际肿瘤学杂志》2023年第10期622-626,共5页Journal of International Oncology

基　　金：河北省财政厅2020年政府资助临床优秀人才培养项目(冀财预复〔2020〕397号)。

摘　　要：放射性认知功能障碍(RICD)起病隐匿, 有效防治措施匮乏。盐酸美金刚作为经典治疗药物, 疗效局限, 寻求多靶点联合用药是必然趋势。近年来, 维生素E、维生素D对认知功能的保护作用受到广泛认可。多项基础研究表明, 维生素E能够通过保护神经元、降低盐酸美金刚引起的不良反应在联合用药中发挥作用;维生素D与盐酸美金刚因具有显著协同效应也已成为目前的研究热点。盐酸美金刚联合维生素治疗方案有望为RICD患者带来更多获益。Radiation-induced cognitive dysfunction(RICD)has an insidious onset and there is a lack of effective prevention and treatment measures.The efficacy of memantine hydrochloride as a classical treatment drug is limited,and it is inevitable to seek multi-target combination drugs.In recent years,the protective effect of vitamin E and vitamin D on cognitive function has been widely recognized.Several basic studies have shown that vitamin E can play a role in the combination of medication by protecting neurons and reducing the adverse effects caused by memantine hydrochloride;Vitamin D and memantine hydrochloride have also become a hot topic of research due to their significant synergistic effects.The combination of memantine hydrochloride and vitamin therapy is expected to bring additional benefits to RICD patients.

关 键 词：放射疗法 认知功能障碍 美金刚 维生素类 

分 类 号：R749.1[医药卫生—神经病学与精神病学]