Disparities in the global burden of tracheal,bronchus,and lung cancer from 1990 to 2019  

作　　者：Chenran Wang Zheng Wu Yongjie Xu Yadi Zheng Zilin Luo Wei Cao Fei Wang Xuesi Dong Chao Qin Liang Zhao Changfa Xia Fengwei Tan Wanqing Chen Ni Li Jie He 

机构地区：[1]Office of Cancer Screening,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China [2]Department of Thoracic Surgery,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China [3]Chinese Academy of Medical Sciences Key Laboratory for National Cancer Big Data Analysis and Implementation,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China

出　　处：《Chinese Medical Journal Pulmonary and Critical Care Medicine》2023年第1期36-45,共10页呼吸与危重症医学（英文）

基　　金：This study was funded by grants from the National Key Research and Development Program of China,Nonprofit Central Research Institute Fund of China(No.2018YFC1315000);National Natural Science Foun-dation of China(No.81871885);Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(No.2019PT320027).

摘　　要：Background:Tracheal,bronchus,and lung(TBL)cancer imposes a high disease burden globally,and its pattern varies greatly across regions and countries.This study aimed to explore the global burden and temporal trends of TBL cancer from 1990 to 2019.Methods:Data on incidence,mortality,and disability-adjusted life years(DALYs)metrics(number,crude rate,and age-standardized rates),and the attributable risk fraction of DALY of TBL cancer from 1990 to 2019 in 21 Global Burden of Disease(GBD)regions,four World Bank income regions,204 countries and territories,and the globe were obtained from the up-to-date GBD 2019 study.We applied estimated annual percentage changes(EAPCs)to the age-standardized incidence rate(ASIR),age-standardized mortality rate(ASMR),and age-standardized DALY rate(ASDR)to quantify the temporal trends of the TBL cancer burden from 1990-2019.Associations of EAPC of age-standardized rates with universal health coverage(UHC)index at the national level were evaluated with Pearson correlation analysis.Results:Globally,approximately 2,260,000 new TBL cancer cases,2,042,600 deaths,and 45,858,000 DALYs were reported in 2019.Combination of all modifiable risk factors,behavioral,environmental,and metabolic risk factors accounted for 79.1%,66.4%,33.3%,and 7.9%of global lung cancer DALYs,respectively.The overall ASIR(EAPC:-0.1[95%confidence interval[CI]:-0.2,-0.1]),ASMR(EAPC:-0.3[95%CI:-0.4,-0.3]),and ASDR(EAPC:-0.7[95%CI:-0.7,-0.6])decreased from 1990 to 2019.The highest mortality rate of TBL cancer occurred in the>85-year-old age group for both sexes among high-income countries(HICs)and upper-middle-income countries(UMCs),and in males aged 80-84 years and females aged>85 years in lower middle-income countries(LMCs).HICs experienced the largest declines in ASIR(-12.6%),ASMR(-20.3%),and ASDR(-27.8%)of TBL cancer between 1990 and 2019,while UMCs had the highest increases in ASIR(16.7%)and ASMR(8.0%)over the period.Eleven(52.4%),14(66.7%),and 15(71.4%)regions of the 21 GBD regions experienced descending trends in ASI

关 键 词：Lung cancer INCIDENCE MORTALITY Disability-adjusted life years Temporal trends 

分 类 号：R734.2[医药卫生—肿瘤]