黄芪建中汤合暖胃汤治疗患儿脾胃虚寒型急性肠胃炎  

Curative effect of Huangqi Jianzhong Decoction combined with Nuanwei Decoction in the treatment of acute gastroenteritis in children with the syndrome of deficient cold of spleen and stomach

作　　者：李海华[1] 宋金岭[1] 张志国[1] 王芳[1] LI Haihua;SONG Jinling;ZHANG Zhiguo;WANG Fang(Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine,Cangzhou 061000,China)

机构地区：[1]河北省沧州中西医结合医院,河北沧州061000

出　　处：《吉林中医药》2024年第4期440-443,共4页Jilin Journal of Chinese Medicine

基　　金：河北省中医药管理局科研计划项目(2021304)。

摘　　要：目的观察黄芪建中汤合暖胃汤治疗脾胃虚寒型急性肠胃炎患儿的疗效。方法选取2021年2月-2023年5月医院收治的74例脾胃虚寒型急性肠胃炎患儿,以随机数字表法分为研究组与对照组,各37例。2组均接受对症治疗,对照组在此基础上采用奥美拉唑肠溶胶囊治疗,研究组在对照组的基础上接受黄芪建中汤合暖胃汤治疗。2组均治疗14 d。对比2组中医证候评分、病症恢复时间、临床疗效、炎症反应、胃肠激素及不良反应。结果治疗后,2组主症评分、次症评分、总评分明显降低(P<0.05),且研究组降低更为明显(P<0.05)。研究组发热、腹痛、呕吐、腹泻等病症恢复时间短于对照组(P<0.05)。研究组总有效率高于对照组(P<0.05)。治疗后,2组白细胞介素-17(IL-17)、基质金属蛋白酶-3(MMP-3)、中性粒细胞与淋巴细胞比值(NLR)水平明显降低(P<0.05),且研究组降低更为明显(P<0.05)。治疗后,2组胃泌素(GSA)水平明显降低(P<0.05),且研究组降低更为明显(P<0.05)。治疗后,2组胃动力素(MTL)水平明显升高(P<0.05),且研究组升高更为明显(P<0.05)。2组不良反应总发生率比较差异无统计学意义(P>0.05)。结论黄芪建中汤合暖胃汤治疗脾胃虚寒型急性肠胃炎患儿疗效确切,可改善患儿临床症状与胃肠功能,促进患儿康复,减轻炎症反应,且安全可靠。Objective To observe the curative effect of Huangqi Jianzhong Decoction combined with Nuanwei Decoction in the treatment of acute gastroenteritis in children with the syndrome of deficient cold of spleen and stomach.Methods A total of 74 acute gastroenteritis children with the syndrome of deficient cold of spleen and stomach admitted to our hospital from February 2021 to May 2023 were selected and divided into a study group(n=37)and a control group(n=37)by random number table method.The two groups both received a symptomatic treatment,while the control group was treated with omeprazole enteric-coated capsules on the basis of that,and the study group was treated with Huangqi Jianzhong Decoction combined with Nuanwei Decoction on the basis of the control group,both for 14 days.The TCM syndrome scores,recovery time,clinical efficacy,inflammatory responses,gastrointestinal hormones and adverse reactions were compared between the two groups.Results After treatment,the main symptom scores,secondary symptom scores and total scores were significantly decreased in the two groups(P<0.05),and the decreases were more obvious in the study group(P<0.05).The symptom recovery time of fever,abdominal pain,vomiting and diarrhea was shorter in the study group than in the control group(P<0.05).The total effective rate was higher in the study group than that in the control group(P<0.05).After treatment,the levels of interleukin-17(IL-17),matrix metalloproteinase-3(MMP-3),neutrophil-lymphocyte ratio(NLR)were significantly decreased in both groups(P<0.05),and they were more significantly decreased in the study group(P<0.05).After treatment,the level of gastrin(GSA)was significantly decreased in the two groups(P<0.05),and the decrease was more significant in the study group(P<0.05).After treatment,the level of motilin(MTL)was significantly increased in the two groups(P<0.05),and the increase was more significant in the study group(P<0.05).There was no difference in the total incidence of adverse reactions between the two groups(P>0.05).

关 键 词：黄芪建中汤 暖胃汤 脾胃虚寒型 急性胃肠炎 小儿 临床疗效 安全性 

分 类 号：R573.3[医药卫生—消化系统]