疏肝理气活血汤联合常规西药治疗慢性萎缩性胃炎临床研究  

Clinical Study on Shugan Liqi Huoxue Decoction Combined with Routine Western Medicine for Chronic Atrophicc Gastritis

作　　者：周镇海 陈锦锋[1] 姚红[1] ZHOU Zhenhai;CHEN Jinfeng;YAO Hong(The Eighth Clinical Medical School of Guangzhou University of Chinese Medicine,Foshan Guangdong 528000,China)

机构地区：[1]广州中医药大学第八临床医学院,广东佛山528000

出　　处：《新中医》2024年第5期76-80,共5页New Chinese Medicine

基　　金：2022年佛山市自筹经费类科技创新项目入库培育项目(2220001005125)。

摘　　要：目的:观察疏肝理气活血汤联合常规西药治疗肝胃不和型慢性萎缩性胃炎(CAG)的临床疗效。方法:选择肝胃不和型CAG患者80例,按照随机数字表法分为观察组和对照组各40例。对照组给予枸橼酸莫沙必利片和瑞巴派特片治疗,观察组在对照组基础上加用疏肝理气活血汤治疗。评价2组临床疗效,比较2组治疗前后中医证候积分及病理检查评分,统计不良反应发生率。结果:观察组总有效率为85.00%,高于对照组70.00%(P<0.05)。治疗后,2组中医证候积分较治疗前下降(P<0.05),且观察组中医证候积分低于对照组(P<0.05)。治疗后,2组胃黏膜萎缩、肠上皮化生、异型增生评分较治疗前下降(P<0.05);且观察组胃黏膜萎缩、肠上皮化生、异型增生评分低于对照组(P<0.05)。观察组不良反应发生率低于对照组(P<0.05)。结论:疏肝理气活血汤联合常规西药治疗CAG可改善患者的临床症状,对于缓解或逆转胃黏膜萎缩、肠上皮化生和异型增生具有一定的治疗效果,且不良反应较少。Objective:To observe the clinical effect of the therapy of Shugan Liqi Huoxue Decoction combined with routine western medicine on chronic atrophic gastritis(CAG)of liver-stomach disharmony type.Methods:A total of 80 CAG patients of liver-stomach disharmony type were selected and divided into the observation group and the control group according to the random number table method,with 4o cases in each group.The control group was treated with Mosapride Citrate Tablets and Rebamipide Tablets,and the observation group was additionally given Shugan Liqi Huoxue Decoction for treatment.The clinical effects in the two groups were evaluated;the traditional Chinese medicine(TCM)syndrome scores and scores of pathology examination were compared before and after treatment between the two groups;the incidence of adverse reactions was counted.Results:The total effective rate was 85.00%in the observation group,higher than that of 70.00%in the control group(P<0.05).After treatment,the TCM syndrome scores in the two groups were decreased when compared with those before treatment(P<0.05),and the TCM syndrome score in the observation group was lower than that in the control group(P<0.05).After treatment,the scores of gastric mucosa atrophy,intestinal metaplasia and dysplasia in the two groups were decreased when compared with those before treatment(P<0.05),and the above scores in the observation group were lower than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion:The therapy of Shugan Liqi Huoxue Decoction combined with routine western medicine can improve the clinical symptoms of CAG patients,and has certain curative effects on the mitigation or reversion of gastric mucosa atrophy,intestinal metaplasia and dysplasia with less adverse reactions.

关 键 词：慢性萎缩性胃炎 肝胃不和证 疏肝理气活血汤 枸橼酸莫沙必利片 瑞巴派特片 中医证候积分 胃黏膜病理 

分 类 号：R573.32[医药卫生—消化系统]