巨噬细胞胞葬功能在急慢性肝病中的作用机制及其靶向治疗  

Mechanism of action of macrophage efferocytosis in acute and chronic liver diseases and related targeted therapy

作　　者：杨焕焕 袁诗雨 唐映梅[1] YANG Huanhuan;YUAN Shiyu;TANG Yingmei(Department of Gastroenterology,The Second Affiliated Hospital of Kunming Medical University,Kunming 650101,China)

机构地区：[1]昆明医科大学第二附属医院消化内科,昆明650101

出　　处：《临床肝胆病杂志》2024年第4期839-843,共5页Journal of Clinical Hepatology

基　　金：国家自然科学基金(82360108);云南省医学领军人才项目(L-2019013);云南万人计划名医专项(YNWR-MY-2018-028);云南省科技人才与平台计划(院士专家工作站202305AF150065);昆明医科大学第二附属医院临床研究项目(2020ynlc010,ynIIT2021017)。

摘　　要：胞葬作用是指吞噬细胞(包括巨噬细胞、树突状细胞等专职吞噬细胞和上皮细胞等非专职吞噬细胞)吞噬并清除凋亡细胞的过程。肝巨噬细胞是肝脏中具有胞葬功能的主要细胞。近年来,越来越多的研究表明包括急性肝损伤、酒精性肝病、非酒精性脂肪性肝病、自身免疫性肝病、肝纤维化及肝细胞癌等在内的多种急慢性肝病均与肝巨噬细胞的胞葬作用有关。本文通过阐述巨噬细胞胞葬相关分子的表达、胞葬过程及其胞葬功能在不同肝病中作用的最新研究进展,旨在为肝病治疗提供新思路。Efferocytosis refers to the process by which apoptotic cells are engulfed and cleared by phagocytes,including professional phagocytes,such as macrophages and dendritic cells,and non-professional phagocytes,such as epithelial cells.Liver macrophages are the main cells with the function of efferocytosis in the liver.In recent years,an increasing number of studies have shown that various acute and chronic liver diseases are associated with the efferocytosis function of liver macrophages,including acute liver injury,alcoholic liver disease,nonalcoholic fatty liver disease,autoimmune liver disease,liver fibrosis,and liver cancer.This article elaborates on the expression of molecules associated with the efferocytosis function of macrophages,the process of efferocytosis,and the role of efferocytosis function in different liver diseases,so as to provide new ideas for the treatment of liver diseases.

关 键 词：肝疾病 巨噬细胞 胞葬 

分 类 号：R575[医药卫生—消化系统]