血清中微小RNA-506、微小RNA-934水平对胰腺癌患者术后生存结局的预测价值  

Predictive value of serum microRNA-506 and microRNA-934 levels in postoperative survival outcome of patients with pancreatic cancer

作　　者：刘晨[1] 叶健文[1] 王雪梅[1] 李桦[1] LIU Chen;YE Jianwen;WANG Xuemei;LI Hua(Department of Hepatobiliary and Pancreatic Surgery,the First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan,450000)

机构地区：[1]郑州大学第一附属医院肝胆胰外科,河南郑州450000

出　　处：《实用临床医药杂志》2024年第5期40-43,共4页Journal of Clinical Medicine in Practice

摘　　要：目的探讨血清中微小RNA-506(miR-506)、微小RNA-934(miR-934)表达水平对胰腺癌患者术后生存结局的预测价值。方法选取接受手术治疗的115例胰腺癌患者为研究组,并根据随访结果分为生存组(n=18)和死亡组(n=97)。选取同期就诊的50例胰腺良性病变患者为对照组;选取同期体检健康的50例志愿者作为健康组。采用实时荧光定量聚合酶链反应(qRT-PCR)检测各组血清中miR-506和miR-934的相对表达水平。采用多因素Logistic回归分析法分析胰腺癌患者术后生存结局的影响因素。采用受试者工作特征(ROC)曲线分析血清miR-506、miR-934对胰腺癌患者术后生存结局的预测价值。结果研究组患者的血清miR-506表达水平低于对照组,差异有统计学意义(P<0.05)。研究组患者的血清miR-934表达水平高于对照组和健康组,差异有统计学意义(P<0.05)。生存组的血清miR-506表达水平高于死亡组,血清miR-934表达水平低于死亡组,差异有统计学意义(P<0.05)。miR-506、miR-934、TNM分期、淋巴结转移是胰腺癌患者术后是否生存的独立影响因素(P<0.05)。结论miR-506在胰腺癌术后死亡患者血清中低表达,miR-934在胰腺癌术后死亡患者血清中高表达。miR-506、miR-934预测胰腺癌患者术后生存结局的价值较高。Objective To investigate the predictive value of serum microRNA-506(miR-506)and microRNA-934(miR-934)expression levels in postoperative survival outcomes of patients with pancreatic cancer.Methods A total of 115 patients with pancreatic cancer who received surgical treatment were selected as the study group,and were divided into survival group(n=18)and death group(n=97)according to the follow-up results.Fifty patients with benign pancreatic lesions in the same period were selected as control group;fifty healthy volunteers were selected as the healthy group.Quantitative real-time polymerase chain reaction(qRT-PCR)was used to detect the relative expression levels of miR-506 and miR-934 in serum of each group.Multivariate Logistic regression analysis was used to analyze the influencing factors of postoperative survival outcomes in patients with pancreatic cancer.The predictive value of serum miR-506 and miR-934 in postoperative survival outcome of pancreatic cancer patients was analyzed by receiver operating characteristic(ROC)curve.Results The expression level of serum miR-506 in the study group was significantly lower than that in the control group(P<0.05).The expression level of serum miR-934 in the study group was significantly higher than that in the control group and healthy group(P<0.05).The expression level of serum miR-506 in the survival group was significantly higher than that in the death group,and the expression level of serum miR-934 was significantly lower than that in the death group(P<0.05).The miR-506,miR-934,TNM stage and lymph node metastasis were independent factors influencing postoperative survival of pancreatic cancer patients(P<0.05).Conclusion The expression of miR-506 is low in the serum of patients who died after pancreatic cancer surgery,and the expression of miR-934 is high in the serum of patients who died after pancreatic cancer surgery.The value of miR-506 and miR-934 in predicting postoperative survival outcome of pancreatic cancer patients is high.

关 键 词：胰腺癌 微小RNA-506 微小RNA-934 生存结局 预测价值 

分 类 号：R735.9[医药卫生—肿瘤] R730.5[医药卫生—临床医学] R446