穴位贴敷联合情志护理对晚期肺癌化疗患者心理状态及免疫功能的影响  

Effect of acupoint application combined with emotional nursing on mental state and immune function of patients with advanced lung cancer undergoing chemotherapy

作　　者：吴燕[1] 张柳柳[2] 吴冰[2] WU Yan;ZHANG Liuliu;WU Bing(Department of Integrated Chinese and Western Medicine,Jiangsu Cancer Hospital,Jiangsu Institute of Cancer Research,the Affiliated Cancer Hospital of Nanjing Medical University,Nanjing,Jiangsu,210009;Nursing Department,Jiangsu Cancer Hospital,Jiangsu Institute of Cancer Research,the Affiliated Cancer Hospital of Nanjing Medical University,Nanjing,Jiangsu,210009)

机构地区：[1]江苏省肿瘤医院/江苏省肿瘤防治研究所/南京医科大学附属肿瘤医院中西医结合科,江苏南京210009 [2]江苏省肿瘤医院/江苏省肿瘤防治研究所/南京医科大学附属肿瘤医院护理部,江苏南京210009

出　　处：《实用临床医药杂志》2024年第6期129-132,138,共5页Journal of Clinical Medicine in Practice

基　　金：江苏省中医药科技发展计划项目(MS2021097)。

摘　　要：目的探讨穴位贴敷加情志护理对晚期肺癌化疗患者心理状态及免疫功能的影响。方法将实施化疗的124例晚期肺癌患者纳入本研究,并随机分为2组,每组62例。对照组行常规护理,观察组行穴位贴敷联合情志护理,观察2组护理干预前后心理状态、生存质量以及恶心、呕吐发生情况。采用放射酶联免疫法检测血液白细胞介素-4(IL-4)、血管内皮生长因子(VEGF)、干扰素-γ(INF-γ)等指标的变化。结果干预前,2组汉密尔顿焦虑量表(HAMA)评分、汉密顿抑郁量表(HAMD)评分比较,差异无统计学意义(P>0.05);干预后,观察组HAMA评分、HAMD评分低于对照组,差异有统计学意义(P<0.05)。干预前,2组症状维度、功能维度评分比较,差异无统计学意义(P>0.05);干预后,观察组症状维度评分低于对照组,功能维度评分高于对照组,差异有统计学意义(P<0.05)。干预后,患者恶心、呕吐发生率下降,生活质量核心量表(EORTCQLQ-30)评分提高,差异有统计学意义(P<0.05)。治疗后,2组INF-γ水平高于治疗前,VEGF、IL-4水平低于治疗前,差异有统计学意义(P<0.05);治疗后,观察组INF-γ水平高于对照组,VEGF、IL-4水平低于对照组,差异有统计学意义(P<0.05)。结论晚期肺癌化疗患者穴位贴敷联合情志护理能够改善不良情绪,降低恶心、呕吐发生率,提高生存质量和护理有效性。Objective To explore the effect of acupoint application and emotional nursing in patients with advanced lung cancer undergoing chemotherapy.Methods A total of 124 patients with advanced lung cancer who underwent chemotherapy in our hospital were randomly divided into two groups,with 62 patients per group.The control group received routine care,while the observation group received acupoint application combined with emotional care.The changes in psychological state and quality of life,occurrence of nausea and vomiting before and after nursing intervention were observed in both groups.The changes of blood interleukin-4(IL-4),vascular endothelial growth factor(VEGF)and interferon-γ(INF-γ)were detected by radioenzyme-linked immunoassay.Results Before the intervention,there was no statistically significant difference in the Hamilton Anxiety Scale(HAMA)scores and Hamilton Depression Scale(HAMD)scores between the two groups(P>0.05).After the intervention,the HAMA and HAMD scores of the observation group were lower than those of the control group(P<0.05).Before the intervention,there was no statistically significant difference in the scores of symptom dimension and function dimension between the two groups(P>0.05).After the intervention,the score of symptom dimension in the observation group was lower than those in the control group,while the score of function dimension was higher than those in the control group(P<0.05).After the intervention,the incidence of nausea and vomiting decreased,and the score of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30(EORTC QLQ-C30)improved(P<0.05).After treatment,the INF-γlevels in both groups were higher than before treatment,while VEGF and IL-4 levels were lower than before treatment(P<0.05).After treatment,the INF-γlevel in the observation group was higher than that in the control group,while the VEGF and IL-4 levels were lower than those in the control group(P<0.05).Conclusion Acupoint application combined with emotional nursi

关 键 词：晚期肺癌 化疗 穴位贴敷 情志护理 免疫因子 恶心 呕吐 

分 类 号：R734.2[医药卫生—肿瘤] R473.73[医药卫生—临床医学] R242