奥美拉唑三联疗法与雷贝拉唑三联疗法治疗慢性胃炎的效果比较  

Comparison of effect of omeprazole triple therapy and rabeprazole triple therapy in the treatment of chronic gastritis

作　　者：刘咪 贺娜 闫红林[1] 蒋宝玲 Liu Mi;He Na;Yan Honglin;Jiang Baoling(Department of Gastroenterology,the First Affiliated Hospital of Xi'an Medical University,Xi'an 710077,China;Endoscopy Center,Yan'an Hospital of Traditional Chinese Medicine,Yan'an 716000,China)

机构地区：[1]西安医学院第一附属医院消化内科,西安710077 [2]延安市中医医院腔镜中心,延安716000

出　　处：《中国实用医刊》2024年第1期90-93,共4页Chinese Journal of Practical Medicine

摘　　要：目的比较奥美拉唑三联疗法与雷贝拉唑三联疗法治疗慢性胃炎的临床效果。方法随机对照研究。抽取2022年3月至2023年3月西安医学院第一附属医院收治的慢性胃炎患者92例,按随机数字表法分为对照组与观察组,每组46例。对照组采用奥美拉唑三联疗法,观察组采用雷贝拉唑三联疗法,两组均持续用药2周。比较两组临床疗效、炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-2R(IL-2R)]、胃功能[胃泌素、胃动素、人表皮生长因子(EGF)、生长抑素]及不良反应。结果观察组临床总有效率(97.83%,45/46)高于对照组(82.61%,38/46),P<0.05。治疗后,观察组TNF-α、IL-6、IL-2R水平低于对照组(P<0.05)。治疗后,观察组胃泌素、EGF水平低于对照组,胃动素、生长抑素水平高于对照组(P均<0.05)。观察组不良反应发生率(4.35%,2/46)与对照组(8.70%,4/46)比较差异未见统计学意义(P>0.05)。结论与奥美拉唑三联疗法相比,雷贝拉唑三联疗法对慢性胃炎的治疗效果更佳,利于减轻炎症反应,改善胃功能,且具有较好安全性。Objective To compare the efficacy of omeprazole triple therapy and rabeprazole triple therapy in the treatment of chronic gastritis.Methods This study was a randomized controlled trail.A total of 92 patients with chronic gastritis admitted to the First Affiliated Hospital of Xi’an Medical University from March 2022 to March 2023 were selected.And they were divided into control group and observation group by random number table method,with 46 cases in each group.The control group received omeprazole triple therapy,while the observation group received rabeprazole triple therapy.Both groups were treated continuously for 2 weeks.The clinical efficacy,inflammatory factors,including tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and interleukin-2R(IL-2R),gastric function assessed by gastrin,motilin,human epidermal growth factor(EGF)and somatostatin,and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group(97.83%,45/46)was higher than that of the control group(82.61%,38/46),P<0.05.After treatment,the levels of TNF-α,IL-6 and IL-2R in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of gastrin and EGF in the observation group were lower than those in the control group,moreover,the levels of motilin and somatostatin in the observation group were higher than those in the control group(all P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group(4.35%,2/46)and the control group(8.70%,4/46),P>0.05.Conclusions Compared with omeprazole triple therapy,rabeprazole triple therapy has a better therapeutic effect in the treatment of chronic gastritis,which is conductive to reducing inflammatory response and improving gastric function,with good safety.

关 键 词：胃炎 奥美拉唑 雷贝拉唑 三联疗法 临床疗效 不良反应 

分 类 号：R573.3[医药卫生—消化系统]