GPER在子宫内膜癌中的作用机制的研究进展  

Research progress on the mechanism of GPER in endometrial cancer

作　　者：戚梦 金玉茜 司露露 刘亚娜 郭瑞霞[1] Qi Meng;Jin Yuxi;Si Lulu;Liu Yana;Guo Ruixia(Department of Gynaecology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院妇科,郑州450052

出　　处：《中国实用医刊》2024年第1期120-122,F0003,共4页Chinese Journal of Practical Medicine

基　　金：国家自然科学基金项目(82273229);国家自然科学联合基金项目(U2004117)

摘　　要：雌激素是人体中一种重要的类固醇激素,可通过多种雌激素受体介导的基因组和快速非基因组途径诱导多效性细胞反应。其中,快速非基因组途径主要由G蛋白偶联雌激素受体(GPER)通过蛋白激酶途径和第二信使介导。目前越来越多证据表明GPER通过激活多种信号通路参与子宫内膜癌的发生发展。因此,从GPER的角度探讨雌激素促进子宫内膜癌进展的作用机制,将为子宫内膜癌的防治提供新的思路。Estrogen is an important steroid hormone in the human body,it can induce pluripotent cellular responses through various estrogen receptor mediated genomic and rapid non-genomic pathways.Among them,the rapid non-genomic pathway is mainly mediated by the G protein-coupled estrogen receptor(GPER)through the protein kinase pathway and the second messenger pathway.Currently,increasing evidence suggests that GPER is involved in the occurrence and development of endometrial cancer by activating multiple signaling pathways.Therefore,investigating the mechanism of estrogen promoting the progression of endometrial cancer from the perspective of GPER will provide new ideas for the prevention and treatment of endometrial cancer.

关 键 词：雌激素 G蛋白偶联雌激素受体 子宫内膜癌 

分 类 号：R737.33[医药卫生—肿瘤]