基于线粒体能量代谢障碍探讨从脾肾论治动脉粥样硬化机制  

Discussion on Mechanism of Treating Atherosclerosis from Perspective of Spleen and Kidney Based on Mitochondrial Energy Metabolism Disorder

作　　者：吴巧敏 常兴 张心爱 关宣可 刘如秀[1] WU Qiaomin;CHANG Xing;ZHANG Xin'ai;GUAN Xuanke;LIU Ruxiu(Guang'anmen Hospital,Chinese Academy of Chinese Medical Sciences,Beijing 100053,China)

机构地区：[1]中国中医科学院广安门医院,北京100053

出　　处：《辽宁中医杂志》2024年第4期58-61,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(81873293);首都临床特色应用研究(Z181100001718184);中央级公益性科研院所基本科研业务费专项资金资助(Z217-XRZ-028)。

摘　　要：动脉粥样硬化是常见的心血管疾病,患病率显著,社会负担重。脾虚失运、肾元匮乏是动脉粥样硬化发病的重要机制。近年来的研究发现,线粒体能量代谢障碍与动脉粥样硬化发病具有密切的联系。中医“脾”“肾”与线粒体的功能具有广泛的关联,脾虚失运、肾元匮乏伴随着线粒体能量代谢障碍。采用健脾、补肾疗法可以减少和延缓动脉粥样硬化,且改善线粒体能量代谢功能。因此,该文基于线粒体能量代谢障碍,探讨从“脾肾论治”动脉粥样硬化的机制,为治疗动脉粥样硬化提供治疗思路。Atherosclerosis is a common cardiovascular disease with significant prevalence and heavy social burden.Spleen deficiency and kidney deficiency are important mechanisms of atherosclerosis.Recent studies have found that mitochondrial energy metabolism disorder is closely related to the pathogenesis of atherosclerosis.“Spleen”and“kidney”in traditional Chinese medicine are widely related to the function of mitochondria.Spleen deficiency and kidney deficiency are accompanied by mitochondrial energy metabolism disorders.Spleen-strengthening and kidney-tonifying therapy can reduce and delay atherosclerosis and improve mitochondrial energy metabolism.Therefore,based on the disorder of mitochondrial energy metabolism,this paper discussed the mechanism of“spleen and kidney treatment”of atherosclerosis,so as to provide therapeutic ideas for the treatment of atherosclerosis.

关 键 词：动脉粥样硬化 脾虚失运 肾元匮乏 线粒体 能量代谢 

分 类 号：R256.2[医药卫生—中医内科学]