急性脑梗死患者血清中MMP-10表达水平与病情严重程度及预后的相关性研究  

Study on correlation of serum MMP-10 expression level with severity and prognosis in patients suffering from acute cerebral infarction

作　　者：张建龙 刘丽[1] 李合华[1] 赵帅 Zhang Jianlong;Liu Li;Li Hehua;Zhao Shuai(Department of Neurology,the First Affiliated Hospital of Xinxiang Medical University,Weihui,Henan 453000,China.)

机构地区：[1]新乡医学院第一附属医院神经内科,河南卫辉453000

出　　处：《齐齐哈尔医学院学报》2024年第6期508-512,共5页Journal of Qiqihar Medical University

基　　金：新乡医学院第一附属医院青年培育基金(QN-2021-B07)。

摘　　要：目的探讨MMP-10在急性脑梗死患者中的表达水平及其与病情严重程度及预后的关系。方法选择2022年2—8月本院神经内科收治的98例急性脑梗死(脑梗死组)患者和56名正常体检者(对照组)作为研究对象,根据NIHSS评分将急性脑梗死患者分为轻度、中度和重度组。检测并比较脑梗死组和对照组血清中MMP-10表达水平的差异,脑梗死组血清中MMP-10表达水平与NIHSS评分的相关性采用Pearson相关分析。对所有急性脑梗死患者随访90 d,根据mRS评分分为预后不良组(mRS评分>2分)和预后良好组(mRS评分≤2分)。比较预后不良组和预后良好组入院时MMP-10表达水平及临床资料的差异。采用Logistic回归分析急性脑梗死患者发生预后不良的危险因素,急性脑梗死患者血清中MMP-10表达水平预测预后不良的临床效能采用ROC曲线分析。结果对照组、轻度脑梗死组、中度脑梗死组和重度脑梗死组中MMP-10表达水平依次显著升高,两两比较差异均在统计学意义(P<0.05)。98例急性脑梗死患者血清中MMP-10表达水平为(84.12±7.12)μg/ml,NIHSS评分为(14.59±2.56)分,两者存在显著正相关性(r=0.771,P<0.05)。根据90 d后mRS评分结果,98例急性脑梗死患者mRS评分>2分39例,mRS评分≤2分59例,与预后良好组相比,NIHSS评分及LDL-c、同型半胱氨酸和MMP-10表达水平在预后不良组中显著升高,差异具有统计学意义(P<0.05)。NIHSS评分(OR=3.281)、LDL-c(OR=2.983)和MMP-10(OR=3.242)是急性脑梗死患者发生预后不良的独立危险因素。ROC曲线结果显示,MMP-10表达水平预测急性脑梗死患者发生预后不良的AUC为0.861,当截断值为89.65μg/ml时,诊断敏感度和特异度分别为89.12%和92.56%。结论急性脑梗死患者血清中MMP-10表达水平显著升高,与病情严重程度及不良预后密切相关。Objective To investigate the serum expression level of MMP-10 in patients suffering from acute cerebral infarction and its relationship with the severity of the disease and prognosis.Methods A total of 98 patients suffering from acute cerebral infarction(ACI group)who were admitted to our hospital from February to August 2022 and 56 normal individuals(control group)were enrolled in our hospital.According to NIHSS scores,acute cerebral infarction patients were divided into mild,moderate and severe groups.The difference in the serum expression level of MMP-10 between ACI group and control group was detected and compared.The correlation between the serum expression level of MMP-10 and NIHSS score in ACI group was analyzed by Pearson analysis.All acute cerebral infarction patients were followed up for 90 days and were divided into poor prognosis group(mRS score over 2)and good prognosis group(mRS score less2)according to mRS scores.The serum expression level of MMP-10 and the clinical data were compared between the poor and the good prognosis group on admission.The Logistic regression was used to analyze the risk factors for poor prognosis in patients with acute cerebral infarction.And the clinical efficiency of serum expression level of MMP-10 in patients with acute cerebral infarction to predict poor prognosis was analyzed by ROC curve.Results The expression level of MMP-10 in serum in control group,mild,moderate and severe acute cerebral infarction group showing an upward trend,and differences of pairwise comparison were statistically significant(P<0.05).The expression level of MMP-10 in serum and NIHSS score in 98 patients suffering from acute cerebral infarction was(84.12±7.12)g/mL and 14.59±2.56,respectively.There was a significant positive correlation between the two index,and the correlation coefficient was 0.771(P<0.05).According to mRS score after 90 days in 98 patients with acute cerebral infarction,a total of 39 cases with the mRS score>2 and the remaining cases with mRS score≤2.Compared with the good

关 键 词：急性脑梗死 MMP-10 NIHSS评分 预后 

分 类 号：R743.3[医药卫生—神经病学与精神病学]