银离子藻酸盐敷料联合重组牛表皮生长因子凝胶换药对肠造口周围脂肪液化合并感染的临床疗效研究  

Study on the clinical efficacy of silver ion alginate dressing combined with recombinant bovine pro-epidermal growth factor gel in the treatment of fat liquefaction and infection around enterostomy

作　　者：朱泽阳 ZHU Ze-yang(Shenzhen Hospital of Southern Medical University,Shenzhen 518000,China)

机构地区：[1]南方医科大学深圳医院,518000

出　　处：《中国实用医药》2024年第6期103-105,共3页China Practical Medicine

摘　　要：目的 探讨银离子藻酸盐敷料联合重组牛表皮生长因子凝胶换药对肠造口周围脂肪液化合并感染的临床疗效。方法 40例行小肠或结肠造口手术且肠造口周围脂肪液化合并感染的结直肠癌、肠梗阻患者,按照随机数字表法分为实验组(21例)和对照组(19例)。两组在常规全身综合治疗基础上均采用常规无菌消毒,对照组给予油纱布块填塞创面,实验组选用银离子藻酸盐敷料联合重组牛表皮生长因子凝胶换药。统计并比较两组治疗1周、2周及1个月创面渗液细菌培养阳性率、创面缩小率以及住院时间。结果 治疗1、2周,实验组创面渗液细菌培养阳性率分别为23.81%、14.29%,均低于对照组的57.89%、42.11%,差异具有统计学意义(P<0.05)。治疗1周,两组患者创面缩小率比较无差异(P>0.05);治疗2周、1个月,实验组患者创面缩小率分别为(31.56±2.47)%、(85.57±4.94)%,均高于对照组的(25.42±1.66)%、(74.28±4.51)%(P<0.05)。实验组患者住院时间(20.19±3.58)d短于对照组的(29.04±5.31)d(P<0.05)。结论 银离子藻酸盐敷料联合重组牛表皮生长因子凝胶换药对于肠造口周围脂肪液化合并感染的患者,能有效促进创面愈合,降低炎症反应,促进患者康复,缩短住院时间,减少住院费用,减轻住院患者及家庭负担。Objective To investigate the clinical efficacy of silver ion alginate dressing combined with recombinant bovine pro-epidermal growth factor gel in the treatment of fat liquefaction and infection around enterostomy.Methods 40 patients with colorectal cancer or intestinal obstruction underwent small intestine or colostomy and combined with fat liquefaction and infection around enterostomy were divided into an experimental group(21 cases)and a control group(19 cases)according to the random numerical table.Both groups were treated with conventional aseptic disinfection on the basis of conventional systemic comprehensive treatment.On this basis,the control group was treated with oil gauze,and the experimental group was treated with silver ion alginate dressing combined with recombinant bovine pro-epidermal growth factor gel.The bacterial culture positivity rate of wound exudate and wound reduction rate at 1 week,2 weeks and 1 month of treatment and hospitalization time of the two groups were counted and compared.Results At 1 and 2 weeks of treatment,the bacterial culture positivity rate of wound exudate in the experimental group were 23.81%and 14.29%,which were lower than 57.89%and 42.11%in the control group,and the difference was statistically significant(P<0.05).At 1 week of treatment,there was no difference in the wound reduction rate between the two groups(P>0.05).At 2 weeks and 1 month of treatment,the wound reduction rates of the experimental group were(31.56±2.47)and(85.57±4.94)%,which were higher than(25.42±1.66)%and(74.28±4.51)%of the control group(P<0.05).The hospitalization time of(20.19±3.58)d in the experimental group was shorter than(29.04±5.31)d in the control group(P<0.05).Conclusion The use of silver ion alginate dressing combined with recombinant bovine pro-epidermal growth factor gel for patients with fat liquefaction and infection around enterostomy can effectively promote wound healing,promote patient rehabilitation,shorten hospitalization time,reduce hospitalization costs,and lighten the bu

关 键 词：银离子藻酸盐敷料 重组牛表皮生长因子凝胶 肠造口周围脂肪液化 感染 

分 类 号：R735.34[医药卫生—肿瘤]