胃癌患者病灶组织CK7、HER2、MLH1、MSH2及MSH6的表达变化研究  

Study on the Expression Change of Lesion Tissue CK7,HER2,MLH1,MSH2 and MSH6 of Patients with Gastric Cancer

作　　者：张黎[1] 朱琳琳 ZHANG Li;ZHU Linlin(Suzhou Xiangcheng People's Hospital,Suzhou 215100,China;不详)

机构地区：[1]苏州市相城人民医院,江苏苏州215100 [2]复旦大学附属肿瘤医院

出　　处：《中外医学研究》2024年第4期58-62,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探究胃癌患者病灶组织角蛋白7(CK7)、人表皮生长因子受体-2(HER2)、错配修复蛋白MutL同源物1(MLH1)、错配修复蛋白MutS同源物2(MSH2)及错配修复蛋白MutS同源物6(MSH6)的表达变化情况。方法:选取2020年2月—2023年1月苏州市相城人民医院收治的120例胃癌患者为研究对象,比较病灶组织及癌旁组织的CK7、HER2、MLH1、MSH2及MSH6的表达情况,并比较不同性别、年龄、TNM分期、分化程度、淋巴结转移情况及病灶位置者的病灶组织CK7、HER2、MLH1、MSH2及MSH6表达情况。结果:胃癌患者病灶组织CK7、HER2阳性率及MLH1、MSH2、MSH6表达缺失率显著高于癌旁组织,差异有统计学意义(P<0.05)。不同性别、年龄及病灶位置病灶组织的CK7、HER2、MLH1、MSH2及MSH6表达比较,差异无统计学意义(P>0.05);Ⅲ期、Ⅳ期病灶组织CK7、HER2阳性率高于Ⅰ期、Ⅱ期,MLH1、MSH2、MSH6表达缺失率均显著低于Ⅰ期、Ⅱ期,差异有统计学意义(P<0.05)。分化程度较低者病灶组织的CK7、HER2阳性率显著高于分化程度较高者,MLH1、MSH2及MSH6表达缺失率显著低于于分化程度较高者,差异有统计学意义(P<0.05)。有淋巴结转移者CK7、HER2阳性率显著高于无淋巴结转移者,MLH1、MSH2及MSH6表达缺失率显著低于无淋巴结转移者,差异有统计学意义(P<0.05)。结论:胃癌患者病灶组织的CK7、HER2、MLH1、MSH2及MSH6的表达相对异常,且不同TNM分期、分化程度及淋巴结转移情况者的差异较大。Objective:To investigate the expression changes of cytokeratin 7(CK7),human epidermal growth factor receptor-2(HER2),mismatch repair protein MutL homolog 1(MLH1),mismatch repair protein MutS homolog 2(MSH2)and mismatch repair protein MutS homolog 6(MSH6)in focal tissues of gastric cancer patients.Method:A total of 120 patients with gastric cancer admitted to Suzhou Xiangcheng People's Hospital from February 2020 to January 2023 were selected as the study objects,the expression of CK7,HER2,MLH1,MSH2 and MSH6 in lesion tissues and adjacent tissues were compared.The expression of CK7,HER2,MLH1,MSH2 and MSH6 in focal tissues of patients with different sex,age,TNM stage,differentiation degree,lymph node metastasis and focal location were compared.Result:The positive rate of CK7 and HER2 and the deletion rate of MLH1,MSH2 and MSH6 expression in focal tissues of gastric cancer patients were significantly higher than those in adjacent tissues,the differences were statistically significant(P<0.05).There were no significant differences in the expression of CK7,HER2,MLH1,MSH2 and MSH6 in focal tissues of different sex,age and lesion location(P>0.05).The positive rates of CK7 and HER2 in focal tissues of stageⅢand stageⅣwere higher than those in stageⅠand stageⅡ,and the expression deletion rates of MLH1,MSH2 and MSH6 were significantly lower than those in stageⅠand stageⅡ,the differences were statistically significant(P<0.05).The positive rates of CK7 and HER2 in the lesion tissues with low differentiation were significantly higher than those with high differentiation,and the expression deletion rates of MLH1,MSH2 and MSH6 were significantly lower than those with high differentiation,the differences were statistically significant(P<0.05).The positive rates of CK7 and HER2 in patients with lymph node metastasis were significantly higher than those without lymph node metastasis,and the expression deletion rates of MLH1,MSH2 and MSH6 were significantly lower than those without lymph node metastasis,the differences w

关 键 词：胃癌 病灶组织 癌旁组织 角蛋白7 人表皮生长因子受体-2 错配修复蛋白MutL同源物1 错配修复蛋白MutS同源物2 错配修复蛋白MutS同源物6 

分 类 号：R735.2[医药卫生—肿瘤]