乳腺癌保乳术后采用APBI-IMRT的效果  

Effect of APBI-IMRT in Breast-conserving Surgery for Breast Cancer

作　　者：谌海波 朱洪雨 孙黎清 CHEN Haibo;ZHU Hongyu;SUN Liqing(The Affiliated Suzhou Hospital of Nanjing University Medicine School,Suzhou 215000,China;不详)

机构地区：[1]南京大学医学院附属苏州医院,江苏苏州215000 [2]苏州市吴中区光福医院

出　　处：《中外医学研究》2024年第4期119-122,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨乳腺癌保乳术后采用加速部分乳腺调强放疗(accelerated partial breast irradiation with intensitymodulated radiation therapy,APBI-IMRT)的效果。方法:选择2018年6月—2022年9月南京大学医学院附属苏州医院收治的82例行乳腺癌保乳术患者作为研究对象,以随机数表法将患者分为对照组与研究组,各41例。对照组应用常规放疗,研究组应用APBI-IMRT,比较两组肿瘤标志物、危险器官剂量、心功能指标。结果:治疗前,两组肿瘤标志物、心功能指标比较,差异无统计学意义(P>0.05);治疗后,两组癌胚抗原(carcinoembryonic antigen,CEA)、β_(2)-微球蛋白(β_(2)-Microglobulin,β_(2)-MG)、细胞角蛋白19片段(cytokeratin 19 fragment,CYFRA21-1)、甲胎蛋白(alpha fetoprotein,AFP)水平、左房收缩末期内径(left atrial end-systolic diameter,LADs)、左室舒张末期内径(left ventricular end diastolic dimension,LVDD)、射血分数(ejection fraction,EF)、左心室短轴缩短率(fraction shortening,FS)较治疗前降低,且研究组肿瘤标志物低于对照组,但心功能指标高于对照组,差异有统计学意义(P<0.05)。研究组危险器官剂量低于对照组,差异有统计学意义(P<0.05)。结论:APBI-IMRT在乳腺癌保乳术后应用可增强治疗效果,降低对心肺功能的损伤。Objective:To evaluate the effect of accelerated partial breast irradiation with intensity-modulated radiation therapy(APBI-IMRT)in patients undergoing breast-conserving surgery for breast cancer.Method:A total of 82 patients who underwent breast-conserving surgery for breast cancer in the Affiliated Suzhou Hospital of Nanjing University Medicine School from June 2018 to September 2022 were selected as the research objects,the patients were divided into the control group and the study group by random number table method,with 41 cases in each group.The control group was treated with conventional radiotherapy,and the study group was treated with APBI-IMRT.The tumor markers,dose of dangerous organs and cardiac function indexes were compared between two groups.Result:Before treatment,there were no significant differences in the tumor markers and cardiac function indexes between two groups(P>0.05).After treatment.the levels of carcinoembryonic antigen(CEA),β_(2)-microglobulin(β_(2)-MG),cytokeratin 19 fragment(CYFRA21-1),alpha fetoprotein(AFP),left atrial end-systolic diameter(LADs),left ventricular end diastolic dimension(LVDD),ejection fraction(EF)and fraction shortening(FS)in two groups were lower than those before treatment,the tumor markers in the study group were lower than those in the control group,but the cardiac function indexes were higher than those in the control group,and the differences were statistically significant(P<0.05).The dose of dangerous organs in the study group was lower than that in the control group,the difference was statistically signifiant(P<0.05).Conclusion:The application of APBI-IMRT after breast-conserving surgery for breast cancer can enhance the therapeutic effect and reduce the damage to cardiopulmonary function.

关 键 词：乳腺癌保乳术 肿瘤标志物 加速部分乳腺调强放疗 心功能 乳腺癌 

分 类 号：R737.9[医药卫生—肿瘤]