The prolactin receptor(PRLR)gene is linked to and associated with the comorbidity of depression and type 2 diabetes in Italian families  

作　　者：Mutaz Amin Rongling Wu Teodor T.Postolache Claudia Gragnoli 

机构地区：[1]INSERM,US14-Orphanet,Paris 75014,France [2]University of Paris,Paris 75013,France [3]Department of Biochemistryand Molecular Biology,Faculty of Medicine,Al-Neelain University,Khartoum 11121,Sudan [4]Department of Public Health Sciences,Penn State College of Medicine,Hershey,PA 17033,USA [5]Department of Statistics,Penn State College of Medicine,Hershey,PA 17033,USA [6]Mood and Anxiety Program,Department of Psychiatry,University of Maryland School of Medicine,Baltimore,MD 21201,USA [7]Rocky Mountain Mental Illness Research Education and Clinical Center(MIRECC),Veterans Integrated Service Network(VISN)19,Military and Veteran Microbiome:Consortium for Research and Education(MVM-CoRE),Denver,CO80246,USA [8]Mental illness Research Education and Clinical Center(MIRECC),Veterans Integrated Service Network(VISN)5,VA Capitol Health Care Network,Baltimore,MD 21090,USA [9]Division of Endocrinology,Department of Medicine,Creighton University School of Medicine,Omaha,NE 68124,USA [10]Molecular Biology Laboratory,Bios Biotech Multi-Diagnostic Health Center,Rome 00197,Italy

出　　处：《Genes & Diseases》2024年第3期15-17,共3页基因与疾病（英文）

摘　　要：Major depressive disorder(MDD)and type 2 diabetes(T2D)are two common complex multifactorial disorders that share several genetic and environmental risk factors such as hypercortisolism and related genes'riskvariants within the stress response and the neuroendocrine hypothalamicpituitary axis.Under stress,the pituitary gland releases prolactin(PRL),whose effects are pleiotropic and include mood control and insulin secretion from the beta cells.1 Variations in the prolactin receptor(PRLR)gene are associated in rodent models with stress level,depressionlike behavior,2 and hepatic insulin sensitivity3 and in humans with maternal glucose homeostasis and gestational diabetes.

关 键 词：diabetes PROLACTIN PITUITARY 

分 类 号：R587.1[医药卫生—内分泌] R749[医药卫生—内科学]